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John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. – 6 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
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All anti-CD20 monoclonal antibodies have similar efficacy and safety risks: Yes.
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- Author(s): Cree, Bruce AC1 (AUTHOR)
- Source:
Multiple Sclerosis Journal. Oct2022, Vol. 28 Issue 12, p1843-1844. 2p.- Subject Terms:
- Source:
- Additional Information
- Abstract: By 2 weeks, 82% of ofatumumab study participants had nearly undetectable peripheral B-cell counts, and by 12 weeks, 98% of participants had undetectable B cells.[5] The difference between ofatumumab and infused MAbs is presumed to be due to the larger drug doses that can be administered intravenously compared to subcutaneously. Thus, rituximab and ofatumumab deplete B cells primarily through complement fixation, whereas ocrelizumab and ublituximab deplete B cells more through ADCC.[1] The net effect of treatment with these antibodies is rapid B-cell depletion to undetectable levels in peripheral blood that is sustained by ongoing treatment. Ocrelizumab depletes B cells in peripheral blood such that by 2 weeks post-treatment B cells are no longer detectable.[2] Rituximab also results in rapid, near-total B-cell depletion 2 weeks after treatment.[3] In a phase 2 study of ublituximab, B-cell counts were reduced by 97%, 24 hours after the first infusion, and by 4 weeks, B-cell depletion was reduced by >99% from baseline.[4] Ofatumumab reduces B cells slightly less rapidly than the other MAbs. [Extracted from the article]
- Abstract: Copyright of Multiple Sclerosis Journal is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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