Dual-wavelength polarimetry for monitoring glucose in the presence of varying birefringence.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Wan Q;Wan Q; Coté GL; Dixon JB
  • Source:
    Journal of biomedical optics [J Biomed Opt] 2005 Mar-Apr; Vol. 10 (2), pp. 024029.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society Country of Publication: United States NLM ID: 9605853 Publication Model: Print Cited Medium: Print ISSN: 1083-3668 (Print) Linking ISSN: 10833668 NLM ISO Abbreviation: J Biomed Opt Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bellingham, WA : Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society, c1996-
    • Subject Terms:
      Lasers* ; Microscopy, Polarization*; Blood Glucose/*analysis; Artifacts ; Birefringence ; Humans ; Models, Theoretical ; Motion
    • Abstract:
      In a continuing effort to develop a noninvasive means of monitoring glucose levels using the aqueous humor of the eye, a dual-wavelength system is developed to show that varying birefringence, similar to what is seen with a moving cornea, can be compensated. In this work, a dual-wavelength, closed-loop system is designed and a model is developed to extract the glucose concentration information. The system and model are tested using various concentrations of glucose in a birefringent test cell subject to motion artifact. The results show that for a static, nonmoving sample, glucose can be predicted to within 10 mg/dl for the entire physiologic range (0 to 600 mg/dl) for either laser wavelength (523 or 635 nm). In the presence of moving birefringence, each individual wavelength produces standard errors on the order of a few thousand mg/dL. However, when the two wavelengths are combined into the developed model, this error is less than 20 mg/dL. The approach shows that multiple wavelengths can be used to drastically reduce the error in the presence of a moving birefringent sample and thus may have the potential to be used to noninvasively monitor glucose levels in vivo in the presence of moving corneal birefringence.
      (Copyright 2005 Society of Photo-Optical Instrumentation Engineers.)
    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20050525 Date Completed: 20050919 Latest Revision: 20190930
    • Publication Date:
      20221213
    • Accession Number:
      10.1117/1.1891175
    • Accession Number:
      15910102