[The effect of transdermal hormone replacement therapy on vasomotor symptoms in perimenopausal women].

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Transliterated Title:
      Wpływ przezskórnej hormonalnej terapii zastepczej na objawy wypadowe u kobiet w okresie okołomenopauzalnym.
    • Source:
      Publisher: Aluna Publishing Country of Publication: Poland NLM ID: 9705467 Publication Model: Print Cited Medium: Print ISSN: 0043-5147 (Print) Linking ISSN: 00435147 NLM ISO Abbreviation: Wiad Lek Subsets: MEDLINE
    • Publication Information:
      Publication: Konstancin Jeziorna : Aluna Publishing
      Original Publication: Warszawa : Pánstwowy Zakład Wydawnictw Lekarskich, [1960-
    • Subject Terms:
    • Abstract:
      About 30% of female population in Poland is already in the perimenopausal age. The North American Menopausal Society has defined the menopause as the permanent cessation of menstruation resulting from the loss of ovarian follicular activity. Perimenopausal period is often connected with vasomotor symptoms in women. In recent years, there has been a growing recognition among clinicians of the importance of learning more about how patients cope with the symptoms of their condition. The aim of the study was to evaluate the effect of hormone replacement therapy on vasomotor symptoms in perimenopausal women with the use of Kupperman Index. In a six-month (6 treatment periods, 28 days each) randomized study, 75 healthy postmenopausal women were assigned to receive 50 micrograms/day of continuous transdermal estradiol with sequential transdermal norethisterone acetate (NETA) in daily doses of 170 micrograms in a single transdermal patch. The average number of vasomotor symptoms per day measured with Kupperman Menopausal Index decreased from prestudy by over 90%. The substantial improvement in vasomotor symptoms assessed across time was apparent by week 12 of the treatment.
    • Accession Number:
      0 (Drug Combinations)
      4TI98Z838E (Estradiol)
      9S44LIC7OJ (Norethindrone Acetate)
      T18F433X4S (Norethindrone)
    • Publication Date:
      Date Created: 20050512 Date Completed: 20050729 Latest Revision: 20181201
    • Publication Date:
      20240829
    • Accession Number:
      15884251