Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM).

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print Cited Medium: Print ISSN: 0953-816X (Print) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE
    • Publication Information:
      Publication: : Oxford : Wiley-Blackwell
      Original Publication: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press, c1989-
    • Subject Terms:
      Membrane Glycoproteins/*biosynthesis ; Nerve Tissue Proteins/*biosynthesis ; Peptide Fragments/*biosynthesis ; Spinal Cord Injuries/*metabolism; Amino Acid Sequence ; Animals ; GPI-Linked Proteins ; Gene Expression Regulation/physiology ; Growth Inhibitors/biosynthesis ; Growth Inhibitors/genetics ; Male ; Membrane Glycoproteins/genetics ; Molecular Sequence Data ; Nerve Tissue Proteins/genetics ; Peptide Fragments/genetics ; Protein Structure, Tertiary ; Rats ; Rats, Inbred Lew ; Spinal Cord Injuries/genetics
    • Abstract:
      The repulsive guidance molecule (RGM) is involved in the formation of the central nervous system (CNS) during development by modulating guidance of growing axons. However, a role of RGM in CNS injury remains to be established. We studied the expression of RGM in the spinal cord of rats with spinal cord injury (SCI). After SCI, RGM+ cells accumulated in lesions and peri-lesional areas. During the first days after SCI, RGM expression was confined to neurons, ballooned neurite fibers/retraction bulbs, smooth muscle/endothelial cells, and to leucocytes infiltrating the lesion. Lesional RGM expression was frequently confined to hypertrophic beta-APP+ and RhoA+ neurites/retraction bulbs. With maturation of the lesion, we observed RGM expression by components of the developing scar tissue (cicatrix), such as fibroblastoid cells, reactive astrocytes and in addition a pronounced extracellular RGM deposition resembling neo-laminae. Frequent RGM+, RhoA+ coexpression by lesional retraction bulbs represent first preliminary evidence of RGM to exert growth inhibitory effects by the second messenger system RhoA. To date, RGM is one of the most potent axonal growth inhibitors identified and present in axonal growth impediments (i) oligodendrocytes; (ii) the plexus choroideus and (iii) components of the developing scar.
    • Molecular Sequence:
      RefSeq XM_218791
    • Accession Number:
      0 (GPI-Linked Proteins)
      0 (Growth Inhibitors)
      0 (Membrane Glycoproteins)
      0 (Nerve Tissue Proteins)
      0 (Peptide Fragments)
      0 (RGM protein, rat)
      0 (Rgma protein, mouse)
    • Publication Date:
      Date Created: 20050423 Date Completed: 20050726 Latest Revision: 20101118
    • Publication Date:
      20221213
    • Accession Number:
      10.1111/j.1460-9568.2005.03962.x
    • Accession Number:
      15845084