乳腺癌对新辅助肌注睾酮 - 阿那曲唑治疗的快速反应的超声评估研究.

Ultrasound Evaluation of Rapid Response of Breast Cancer to Neoadjuvant Intramuscular Injection of Testosterone-anastrozole.

Objective: To explore the feasibility of using ultrasound to evaluate the clinical efficacy of neoadjuvant chemotherapy (NAC) breast cancer patients receiving intramuscular injection of testosterone anastrozole, in order to identify reliable indicators that can be used to evaluate the efficacy of NAC in breast cancer. 100 patients with breast cancer (100 lesions) who received treatment in our hospital from January 2018 to January 2021 were selected as the research objects. They were subjected to ultrasonic examination before and after chemotherapy, and the two-dimensional ultrasound index (including tumor shape, border, internal echo, posterior echo) and color Doppler ultrasound index were recorded(including blood flow grade, blood flow resistance index (RI), maximum systolic blood flow velocity (PSV)), ultrasonic elastic imaging indexes (including elastic score and elastic strain rate(SR)), the patients were divided into effective group (MHR group) and ineffective group (nmhr group) according to the pathological results after chemotherapy Compare the difference of the above parameters between the two groups before and after chemotherapy, and carry out univariate and multivariate Logistic regression analysis to find out the indexes that can be applied to evaluate the efficacy of NAC in breast cancer patients, and calculate the diagnostic efficiency of these parameters by drawing ROC curve. (1) In terms of qualitative parameters, there was difference between MHR and nmhr groups in the changes of internal echo, blood flow grade and elasticity score after NAC treatment (P<0.05); in terms of quantitative parameters, RI, Sr and PSV in MHR group were lower than those in nmhr group after chemotherapy (P<0.05); (2) The ROC curves of RI, SR and PSV respectively for breast cancer patients receiving intramuscular injection of testosterone anastrozole NAC were respectively drawn. The AUC curves were 0.811 (95% CI=0.666-0.956, P=0.002), 0.697 (95% CI=0.524-0.869, P=0.038), 0.734 (95% CI=0.570-0.897, P=0.011); (3) Univariate analysis of internal echo, blood flow classification, elastic score, RI, SR and PSV were the influencing factors of NAC efficacy in breast cancer patients. Multivariate Logistic regression analysis showed that RI, SR and PSV could affect the NAC efficacy of breast cancer patients (P<0.05). Ultrasound has a good application value in evaluating the efficacy of intradermal injection of testosterone anastrozole NAC in breast cancer patients. RI, SR and PSV can reliably evaluate the early efficacy of NAC in breast cancer, which can be considered for clinical application. [ABSTRACT FROM AUTHOR]

目的：探究使用超声对接受肌注睾酮 - 阿那曲唑新辅助治疗（NAC）乳腺癌患者临床疗效评估的可行性，以期找出能够用于 评估乳腺癌 NAC 疗效的可靠指标。方法：选择 2018 年 1 月至 2021 年 1 月于我院接受治疗的 100 例乳腺癌患者（100 个病灶）为 研究对象，分别于其接受化疗前和化疗后实施超声检测，记录入组患者二维超声指标（包括肿瘤形态、边界、内部回声、后方回 声）、彩色多普勒超声指标（包括血流分级、血流阻力指数（RI）、收缩期最高血流速度（PSV））、超声弹性成像指标（包括弹性评分、 弹性应变率（SR）），将入组患者按照化疗后病理结果区分为有效组（MHR 组）和无效组（NMHR 组），对比两组患者化疗前后上述 参数的差异，分别对上述参数实施单因素和多因素 Logistic 回归分析，并通过绘制受试者工作特征曲线（ROC）的方式计算上述参 数的诊断效能。结果：（1）定性参数方面，NAC 治疗后 MHR 和 NMHR 组患者在病灶内部回声变化、血流分级变化、弹性评分变化 方面具有差异（P<0.05）；定量参数方面，化疗结束后 MHR 组患者的 RI、SR 以及 PSV 均明显低于 NMHR 组（P<0.05）；（2）RI、SR 以及 PSV 对乳腺癌患者接受肌注睾酮 - 阿那曲唑 NAC 治疗有效性的 ROC 曲线，其 AUC 分别为 0.811（95% CI=0.666-0.957， P=0.002）、0.697（95% CI=0.524-0.869，P=0.038）、0.734（95% CI=0.570-0.897，P=0.011）；（3）单因素分析内部回声、血流分级、弹性评 分、RI、SR 以及 PSV 是乳腺癌患者 NAC 疗效影响因素，多因素 Logistic 回归分析 RI、SR 以及 PSV 会影响乳腺癌患者 NAC 疗效 （P<0.05）。结论：超声在评估乳腺癌患者接受肌注睾酮 - 阿那曲唑 NAC 治疗有效性具有较好的应用价值，其中 RI、SR 及 PSV 可 对乳腺癌 NAC 早期疗效做出可靠评估，可考虑将其应用于临床中。 [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)