Abstract Supplement Abstracts from AIDS 2022 ‐ the 24th International AIDS Conference, 29 July – 2 August 2022, Montréal, Canada & Virtual.

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  • Additional Information
    • Subject Terms:
      MONTREAL (Quebec); CANADA
    • Abstract:
      The retinoid (10mM) increased viral reactivation mediated by IL-15 to a similar extent as HODHBt (100mM) but unlike HODHBt, specifically promoted cell death of latently infected cells compared to controls when combined with IL-15. This indicates that the retinoid is able to reactivate latent HIV through a mechanism mediated by IL-15 but not directly dependent on STAT5 phosphorylation. Among the clinically relevant latency reversing agents (LRA) under investigation, IL-15 or the IL-15 superagonist N-803 have been shown to reactivate latent HIV I ex vivo i and I in vivo i . [Extracted from the article]
    • Abstract:
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