Acrospora C-10 mechanistic exploration of the regulation of sorbicillinoids biosynthesis by sorR1.

Cephalosporin C was produced by the filamentous fungus acrospora C-10 SorR1 production, belonging to B-Lactam antibiotics. Its modified 7-aminocefanoic acid is an important intermediate for cephems antibiotics. Cephalosporins have a huge share in the antibiotic market at home and abroad, and are the main anti infective drugs in the clinic. Sorbicillinoids are typical six membered alcohols with molecular formula C6H14O6, CA registry number [50-70-4] found in fruits and berries in nature. In this paper, the definitions of acremonium C-10 sorR1 and sorbicillides were introduced in detail, and the biosynthetic mechanism of sorbicillides combined with acremonium C-10 sorR1 was studied. In this study, the in vitro kinetic data related to the biosynthesis of Sorbicillinoids were collected, and the production in batch culture was simulated. The simulation results are basically consistent with the reported experimental data. [ABSTRACT FROM AUTHOR]

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