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West Ashley Library
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Phone: (843) 766-6635
Wando Mount Pleasant Library
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Village Library
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St. Paul's/Hollywood Library
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Otranto Road Library
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McClellanville Library
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John L. Dart Library
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Antiphospholipid antibodies and vitamin D deficiency in COVID-19 infection with and without venous or arterial thrombosis: A pilot case-control study.
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- Author(s): Shah, Ruchi1 (AUTHOR); Mohammed, Yaqub Nadeem1 (AUTHOR); Koehler, Tracy J.2 (AUTHOR); Kaur, Jasmeet1 (AUTHOR); Toufeili, Margarita1 (AUTHOR); Pulipati, Priyanjali1 (AUTHOR); Alqaysi, Ahmed1 (AUTHOR); Khan, Ali1 (AUTHOR); Khalid, Mahrukh1 (AUTHOR); Lee, Yi1 (AUTHOR); Dhillon, Parveen3 (AUTHOR); Dan, Anna Thao3 (AUTHOR); Kumar, Nicholas3 (AUTHOR); Bowen, Monica2 (AUTHOR); Sule, Anupam A.1 (AUTHOR); Krishnamoorthy, Geetha1 (AUTHOR)
- Source:
PLoS ONE. 7/14/2022, Vol. 17 Issue 7, p1-13. 13p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Background: Coronavirus disease-2019 (COVID-19) is associated with thromboembolism. Antiphospholipid antibody (APLa) formation is one of the mechanisms. Vitamin D deficiency has been associated with thrombosis in antiphospholipid antibody syndrome. Objective: Measure APLa and vitamin D in hospitalized COVID-19 patients with and without thrombosis to evaluate if thromboembolism is associated with concomitant APLa and vitamin D deficiency. Methods: Case-control study. Hospitalized COVID-19 patients with a thromboembolic event (ischemic stroke, myocardial infarction, deep venous thrombosis/pulmonary embolism, Cases n = 20). Controls (n = 20): Age, sex-matched without thromboembolic events. Patients with autoimmune disorders, antiphospholipid antibody syndrome, thrombophilia, anticoagulation therapy, prior thromboembolism, chronic kidney disease 3b, 4, end-stage renal disease, and malignancy were excluded. Given the limited current literature on the role of concomitant antiphospholipid antibodies and vitamin D deficiency in causing venous and/or arterial thrombosis in hospitalized COVID-19 patients, we enrolled 20 patients in each arm. Anti-cardiolipin IgG/IgM, beta-2 glycoprotein-1 IgG/IgM, lupus anticoagulant and vitamin D levels were measured in both groups. Results: Cases were 5.7 times more likely to be vitamin D deficient (OR:5.7, 95% CI:1.3–25.6) and 7.4 times more likely to have any one APLa (OR:7.4, 95% CI: 1.6–49.5) while accounting for the effects of sex. Patients with both APLa and vitamin D deficiency had significantly more thrombosis compared to patients who were antibody positive without vitamin D deficiency (100% vs 47.4%; p = 0.01). Conclusions: Thrombosis in COVID-19 was associated with concomitant APLa and vitamin D deficiency. Future studies in COVID-19 should assess the role of vitamin D in reducing thrombosis. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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