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West Ashley Library
9 a.m. - 5 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. - 5 p.m.
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Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 5 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 5 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 5 p.m.
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McClellanville Library
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John's Island Library
9 a.m. - 5 p.m.
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Folly Beach Library
9 a.m. - 2 p.m.
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*open the 2nd and 4th Saturday
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Miss Jane's Building (Edisto Library Temporary Location)
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Bone regeneration in rat using polycaprolactone/gelatin/epinephrine scaffold.
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- Author(s): Ehterami, Arian1 (AUTHOR); Khastar, Hossein2,3 (AUTHOR); Soleimannejad, Mostafa4 (AUTHOR); Salehi, Majid2,5,6 (AUTHOR); Nazarnezhad, Simin7 (AUTHOR); Majidi Ghatar, Jila8 (AUTHOR); Bit, Arindam9 (AUTHOR); Jafarisani, Moslem3 (AUTHOR); Abbaszadeh-Goudarzi, Ghasem10 (AUTHOR); Shariatifar, Nabi11 (AUTHOR)
- Source:
Drug Development & Industrial Pharmacy. Dec2021, Vol. 47 Issue 12, p1915-1923. 9p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Solid supports like the extracellular matrix network are necessary for bone cell attachment and start healing in the damaged bone. Scaffolds which are made of different materials are widely used as a supportive structure in bone tissue engineering. In the current study, a 3D polycaprolactone/gelatin bone scaffold was developed by blending electrospinning and freeze-drying techniques for bone tissue engineering. To improve the efficiency of the scaffold, different concentrations of epinephrine (EP) due to its effect on bone healing were loaded. Fabricated scaffolds were characterized by different tests such as surface morphology, FTIR, porosity, compressive strength, water contact angle, and degradation rate. The interaction between prepared scaffolds and blood and cells was evaluated by hemolysis, and MTT test, respectively, and bone healing was evaluated by a rat calvaria defect model. Based on the results, the porosity of scaffolds was about 75% and by adding EP, mechanical strength decreased while due to the hydrophilic properties of it, degradation rate increased. In vivo and in vitro studies showed the best cell proliferation and bone healing were in PCL/gelatin/EP1% treated group. These results showed the positive effect of fabricated scaffold on osteogenesis and bone healing and the possibility of using it in clinical trials. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Drug Development & Industrial Pharmacy is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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