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Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma.
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- Author(s): Hawrylowicz CM;Hawrylowicz CM; O'Garra A
- Source:
Nature reviews. Immunology [Nat Rev Immunol] 2005 Apr; Vol. 5 (4), pp. 271-83.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Review
- Language:
English
- Additional Information
- Source:
Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124169 Publication Model: Print Cited Medium: Print ISSN: 1474-1733 (Print) Linking ISSN: 14741733 NLM ISO Abbreviation: Nat Rev Immunol Subsets: MEDLINE
- Publication Information:
Original Publication: London, UK : Nature Pub. Group, [c2001-
- Subject Terms:
- Abstract:
Allergic diseases are caused by aberrant T-helper-2 immune responses in susceptible individuals. Both naturally occurring CD4(+)CD25(+) regulatory T cells and inducible populations of antigen-specific interleukin-10-secreting regulatory T cells inhibit these inappropriate immune responses in experimental models. This article discusses the evidence that regulatory T-cell function might be impaired in allergic and asthmatic disease and that certain therapeutic regimens might function, at least in part, to promote regulatory T-cell generation. Current research strategies seek to exploit these observations to improve the generation of allergen-specific regulatory T-cell populations with the potential to provide the safe and long-term alleviation of disease symptoms.
- Number of References:
188
- Grant Information:
MC_U117565642 United Kingdom MRC_ Medical Research Council
- Accession Number:
0 (Adjuvants, Immunologic)
130068-27-8 (Interleukin-10)
- Publication Date:
Date Created: 20050319 Date Completed: 20050510 Latest Revision: 20220317
- Publication Date:
20231215
- Accession Number:
10.1038/nri1589
- Accession Number:
15775993
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