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Porcine Fibrin Sealant Promotes Skin Wound Healing in Rats.
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- Author(s): Zhang, Lihuo (AUTHOR); Liu, Lu (AUTHOR); Zhang, Jundong (AUTHOR); Zhou, Ping (AUTHOR)
- Source:
Evidence-based Complementary & Alternative Medicine (eCAM). 6/23/2022, p1-10. 10p. 2 Color Photographs, 1 Black and White Photograph, 1 Chart, 2 Graphs. - Source:
- Additional Information
- Subject Terms: SKIN injuries; WOUND care; WOUND healing; FIBRIN tissue adhesive; FIBROBLAST growth factors; TRANSFORMING growth factors-beta; COLLAGEN; STAINS & staining (Microscopy); MINERAL oils; ANIMAL experimentation; EPIDERMAL growth factor; WESTERN immunoblotting; NEOVASCULARIZATION; SWINE; CELL physiology; TREATMENT effectiveness; RATS; GENE expression; COMPARATIVE studies; ENZYME-linked immunosorbent assay; MESSENGER RNA; CELL proliferation; STATISTICAL sampling; POLYMERASE chain reaction; VASCULAR endothelial growth factors; ANTIGENS; EVALUATION; BLOOD; METABOLISM
- Abstract: Objective. Fibrin sealant (FS) is widely used for skin wound healing, but data on porcine FS (PFS), a new type of FS, are limited. This study investigated the effects and potential mechanisms of porcine fibrin sealant (PFS) on skin wound healing in rats. Methods. Traumatic rats were randomly divided into three groups: control, PFS, and medical Vaseline. The wound area and wound index of the rats were measured within 14 days after surgery. Hematoxylin-eosin (H&E) staining and Masson staining were used to observe the pathological images and collagen formation on the wounded skin, respectively. To investigate the healing mechanisms, the enzyme-linked immunosorbent assay (ELISA) was used to detect platelet endothelial cell adhesion molecule-1 (CD31) and cluster of differentiation 34 (CD34) expression in the wounded skin. Additionally, quantitative real-time PCR (qRT-PCR) was used to evaluate the mRNA levels of the vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and epidermal growth factor (EGF), and transforming growth factor-β1 (TGF-β1). Meanwhile, TGF-β1 protein expression was assessed by Western blot analysis. Results. Compared with the control group, both PFS and medical Vaseline treatment significantly reduced the wounded area and increased the wound closure rate. H&E staining showed that the cells in the PFS group proliferated rapidly, and the epidermis and dermis were thickened to some extent with a clear epidermal cell structure. Moreover, PFS promoted the formation of collagen and significantly increased the levels of CD31 and CD34 and the growth factors in the skin tissues of the traumatic rats. Conclusion. PFS effectively promoted skin wound healing, especially in tissue formation, reepithelialization, angiogenesis, and collagen deposition, in traumatic rat models. This study provides a new strategy and scientific foundation for PFS application in skin wound healing. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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