ЕНДОТЕЛНА ДИСФУНКЦИЯ - ВРЪЗКА С АНТИФОСФОЛИПИДНИТЕ АНТИТЕЛА (Bulgarian)

ENDOTHELIAL DYSFUNCTION - ASSOCIATION WITH ANTIPHOSPHOLIPID ANTIBODIES. (English)

The endothelium is a thin monocellular layer that covers the inner surface of the blood vessels. It is responsible for maintaining the balance between the different factors involved in vascular homeostasis. Various risk factors can impair the functional capacity of endothelial cells, causing the so-called endothelial dysfunction. Endothelial dysfunction and vascular inflammation play major roles in the pathogenesis and clinical outcomes of patients with cardio-vascular diseases. It is characterised by vasospasm, local coagulation alterations, abnormal fibrinolysis, and increase in arterial wall proliferation. Antiphospholipid antibodies (aPL) are one of these risk factors that can promote endothelial dysfunction, inflammation and procuagulation state. Their pathogenic and damaging role on endothelial cells has been demonstrated in several experimental models. The better understanding and knowledge of the mechanisms of endothelial dysfunction in patients with aPL and/or antiphospholipid syndrome (APS) would facilitate the improvement of current treatment regimens, which are ineffective for some groups of patients. [ABSTRACT FROM AUTHOR]

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