PCB exposure and in vivo CYP1A2 activity among Native Americans.

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  • Author(s): Fitzgerald EF;Fitzgerald EF; Hwang SA; Lambert G; Gomez M; Tarbell A
  • Source:
    Environmental health perspectives [Environ Health Perspect] 2005 Mar; Vol. 113 (3), pp. 272-7.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Print ISSN: 0091-6765 (Print) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
    • Subject Terms:
      Environmental Exposure* ; Food Contamination* ; Indians, North American*; Cytochrome P-450 CYP1A2/*pharmacology ; Environmental Pollutants/*poisoning ; Polychlorinated Biphenyls/*poisoning; Adolescent ; Adult ; Aged ; Animals ; Biomarkers/analysis ; Cross-Sectional Studies ; Female ; Fishes ; Humans ; Male ; Middle Aged ; New York ; Ontario ; Polychlorinated Biphenyls/blood ; Pregnancy ; Quebec ; Seafood ; Sex Factors
    • Abstract:
      Cytochrome P-450 1A2 (CYP1A2) is an enzyme involved in the metabolic activation of some carcinogens and is believed to be induced by xenobiotics. Very few studies, however, have investigated the association between environmental exposures and in vivo CYP1A2 activity in humans. To address this issue, a study was conducted of CYP1A2 activity among Native Americans exposed to polychlorinated biphenyls (PCBs) from the consumption of fish from the St. Lawrence River. At the Mohawk Nation at Akwesasne (in New York and in Ontario and Quebec, Canada), 103 adults were interviewed, and they donated blood for serum PCB analysis and underwent the caffeine breath test (CBT), a safe and noninvasive procedure that uses caffeine as a probe for CYP1A2 activity in vivo. The results supported the findings of other studies that CBT values are higher among smokers and men and lower among women who use oral contraceptives. Despite a relatively low average total PCB body burden in this population, the sum of serum levels for nine mono- or di-ortho-substituted PCB congeners showed positive associations with CBT values (p = 0.052 wet weight and p = 0.029 lipid adjusted), as did toxic equivalent quantities (TEQs; p = 0.091 for wet weight and 0.048 for lipid adjusted). Regarding individual congeners, serum levels of PCB-153, PCB-170, and PCB-180 were significantly correlated with CBT values. The results support the notion that CYP1A2 activity may be a marker of an early biological effect of exposure to PCBs in humans and that the CBT may be a useful tool to monitor such effects.
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    • Grant Information:
      11256 United States PHS HHS; 2P4204913 United States PHS HHS
    • Accession Number:
      0 (Biomarkers)
      0 (Environmental Pollutants)
      DFC2HB4I0K (Polychlorinated Biphenyls)
      EC 1.14.14.1 (Cytochrome P-450 CYP1A2)
    • Publication Date:
      Date Created: 20050304 Date Completed: 20050718 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      PMC1253751
    • Accession Number:
      10.1289/ehp.7370
    • Accession Number:
      15743714