Mortality and causes of death in persons with Down syndrome in California.

Publisher: Blackwell Country of Publication: England NLM ID: 0006761 Publication Model: Print Cited Medium: Print ISSN: 0012-1622 (Print) Linking ISSN: 00121622 NLM ISO Abbreviation: Dev Med Child Neurol Subsets: MEDLINE

Publication: <2010->: Oxford : Blackwell
Original Publication: 1962- : London : National Spastics Society Medical Education and Information

Cause of Death/*trends ; Down Syndrome/*mortality ; Ethnicity/*statistics & numerical data; Adolescent ; Adult ; Aged ; California ; Cardiovascular Diseases/ethnology ; Cardiovascular Diseases/mortality ; Child ; Child, Preschool ; Congenital Abnormalities/ethnology ; Congenital Abnormalities/mortality ; Down Syndrome/ethnology ; Female ; Follow-Up Studies ; Heart Defects, Congenital/ethnology ; Heart Defects, Congenital/mortality ; Humans ; Infant ; Leukemia/ethnology ; Leukemia/mortality ; Life Expectancy/trends ; Life Tables ; Male ; Middle Aged ; Respiratory Tract Diseases/ethnology ; Respiratory Tract Diseases/mortality ; Survival Rate

This study investigated mortality and causes of death between 1988 and 1999 in 14781 persons (6702 female) with Down syndrome in California, comparing age, sex, ethnicity, and other factors. Mean age at the start of follow-up was 14 years 8 months (SD 14y 10mo). During the study period 600 persons died. The standardized mortality ratio (SMR) for the population was 5.5. Blacks were at greater risk than whites, Hispanics, or Asians (relative risk = 1.5). Mortality declined during the period, especially for children with congenital heart defects. Leukemia (SMR = 17), respiratory illnesses (SMR = 27), congenital anomalies (SMR = 72), and circulatory diseases (SMR = 5.3) accounted for most of the excess mortality. With the exception of leukemia, cancer mortality was not different from that of the general population.

Date Created: 20050303 Date Completed: 20050316 Latest Revision: 20211203

20231215

10.1017/s0012162205000319

15739721