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West Ashley Library
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Phone: (843) 766-6635
Folly Beach Library
Closed (2024 - Labor Day)
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
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Phone: (843) 883-3914
Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
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Phone: (843) 884-9741
St. Paul's/Hollywood Library
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Phone: (843) 889-3300
Otranto Road Library
Closed (2024 - Labor Day)
Phone: (843) 572-4094
Mt. Pleasant Library
Closed (2024 - Labor Day)
Phone: (843) 849-6161
McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Miss Jane's Building (Edisto Library Temporary Location)
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
T-Cell Immunotherapy against Mutant KRAS for Pancreatic Cancer.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): J. M., Cornelis; Melief, M. D.
- Source:
New England Journal of Medicine. 6/2/2022, Vol. 386 Issue 22, p2143-2144. 2p. - Source:
- Additional Information
- Subject Terms:
- Abstract: The author shares insight on T-cell immunotherapy against mutant Kirsten rat sarcoma virus (KRAS) for pancreatic cancer. The author discusses results of a research on the therapeutic use of autologous T cells transduced with two T-cell receptors (TCR) directed against the mutant KRAS molecule G12D expressed by the cancer cells in a 67-year old female. Emphasis is given on the need to explore potential failure mechanisms for T-cell therapy such as increased WNT-beta-catenin signaling.
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