Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Lu L;Lu L; Zhang LL; Li GJ; Guo W; Liang W; Zheng W
  • Source:
    Neurotoxicology [Neurotoxicology] 2005 Mar; Vol. 26 (2), pp. 257-65.
  • Publication Type:
    Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print Cited Medium: Print ISSN: 0161-813X (Print) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE
    • Publication Information:
      Publication: 2001- : Amsterdam : Elsevier Science
      Original Publication: Park Forest South, Ill., Pathotox Publishers.
    • Subject Terms:
      Welding*; Air Pollutants, Occupational/*adverse effects ; Ferritins/*blood ; Inhalation Exposure/*adverse effects ; Iron/*blood ; Manganese/*blood ; Occupational Exposure/*adverse effects ; Receptors, Transferrin/*blood; Adult ; Air Pollutants, Occupational/blood ; Biomarkers/blood ; Female ; Ferritins/biosynthesis ; Humans ; Male ; Middle Aged ; Receptors, Transferrin/antagonists & inhibitors
    • Abstract:
      This study was performed to determine airborne manganese levels during welding practice and to establish the relationship between long-term, low-level exposure to manganese and altered serum concentrations of manganese, iron, and proteins associated with iron metabolism in career welders. Ninety-seven welders (average age of 36 years) who have engaged in electric arc weld in a vehicle manufacturer were recruited as the exposed group. Welders worked 7-8h per day with employment duration of 1-33 years. Control subjects consisted of 91 employees (average age of 35 years) in the same factory but not in the welding profession. Ambient manganese levels in welders' breathing zone were the highest inside the vehicle (1.5 +/- 0.7 mg/m3), and the lowest in the center of the workshop (0.2 +/- 0.05 mg/m3). Since the filter size was 0.8 microm, it is possible that these values may be likely an underestimation of the true manganese levels. Serum levels of manganese and iron in welders were about three-fold (p < 0.01) and 1.2-fold (p < 0.01), respectively, higher than those of controls. Serum concentrations of ferritin and transferrin were increased among welders, while serum transferrin receptor levels were significantly decreased in comparison to controls. Linear regression analyses revealed a lack of association between serum levels of manganese and iron. However, serum concentrations of iron and ferritin were positively associated with years of welder experience (p < 0.05). Moreover, serum transferrin receptor levels were inversely associated with serum manganese concentrations (p < 0.05). These findings suggest that exposure to welding fume among welders disturbs serum homeostasis of manganese, iron, and the proteins associated with iron metabolism. Serum manganese may serve as a reasonable biomarker for assessment of recent exposure to airborne manganese.
    • References:
      J Neurosci Res. 1999 Apr 15;56(2):113-22. (PMID: 10777372)
      Toxicol Sci. 2000 Apr;54(2):295-301. (PMID: 10774811)
      Appl Occup Environ Hyg. 2000 Oct;15(10):746-50. (PMID: 11036725)
      Neurology. 2001 Jan 9;56(1):8-13. (PMID: 11148228)
      Brain Res. 2001 Apr 6;897(1-2):175-9. (PMID: 11282372)
      Toxicol Appl Pharmacol. 2001 Sep 1;175(2):160-8. (PMID: 11543648)
      Neurology. 2003 Jan 14;60(1):74-7. (PMID: 12525721)
      J Occup Environ Med. 2004 Mar;46(3):241-8. (PMID: 15091287)
      Neurology. 1967 Feb;17(2):128-36. (PMID: 6066873)
      Clin Chem. 1974 Mar;20(3):360-4. (PMID: 4813392)
      Adv Neurol. 1976;14:339-52. (PMID: 821321)
      Clin Toxicol. 1981 Apr;18(4):407-16. (PMID: 7237969)
      Acta Neuropathol. 1986;70(3-4):273-8. (PMID: 3766127)
      Am J Ind Med. 1987;11(3):307-27. (PMID: 3578289)
      Fundam Appl Toxicol. 1987 Aug;9(2):314-28. (PMID: 3653574)
      Br J Ind Med. 1989 Dec;46(12):856-9. (PMID: 2611159)
      J Neurochem. 1991 Mar;56(3):978-82. (PMID: 1704426)
      Brain. 1991 Aug;114 ( Pt 4):1953-75. (PMID: 1832073)
      Mov Disord. 1993;8(1):1-12. (PMID: 8419792)
      Cell. 1993 Jan 15;72(1):19-28. (PMID: 8380757)
      Dementia. 1993 Mar-Apr;4(2):61-5. (PMID: 8358514)
      Environ Res. 1994 Feb;64(2):151-80. (PMID: 8306949)
      Neurology. 1994 Sep;44(9):1583-6. (PMID: 7936278)
      J Neurochem. 1995 Aug;65(2):710-24. (PMID: 7616227)
      Brain Res. 1995 Oct 9;695(1):53-8. (PMID: 8574647)
      Occup Environ Med. 1996 Jan;53(1):32-40. (PMID: 8563855)
      Neurology. 1996 Feb;46(2):492-8. (PMID: 8614520)
      Biol Trace Elem Res. 1996 Oct-Nov;55(1-2):39-54. (PMID: 8971353)
      Neurology. 1997 Mar;48(3):650-8. (PMID: 9065542)
      Neurology. 1997 Sep;49(3):714-7. (PMID: 9305329)
      Brain Res. 1998 Jul 20;799(2):334-42. (PMID: 9675333)
      Brain Res. 1999 Jun 26;833(1):125-32. (PMID: 10375687)
      Neurotoxicology. 1999 Apr-Jun;20(2-3):173-80. (PMID: 10385881)
      Neurotoxicology. 1999 Apr-Jun;20(2-3):327-42. (PMID: 10385894)
      NMR Biomed. 2004 Dec;17(8):544-53. (PMID: 15617053)
    • Grant Information:
      ES-08146 United States ES NIEHS NIH HHS; ES-09089 United States ES NIEHS NIH HHS; R01 ES008146 United States ES NIEHS NIH HHS; R56 ES008146 United States ES NIEHS NIH HHS; P30 ES009089 United States ES NIEHS NIH HHS
    • Accession Number:
      0 (Air Pollutants, Occupational)
      0 (Biomarkers)
      0 (Receptors, Transferrin)
      42Z2K6ZL8P (Manganese)
      9007-73-2 (Ferritins)
      E1UOL152H7 (Iron)
    • Publication Date:
      Date Created: 20050217 Date Completed: 20050503 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      PMC4002285
    • Accession Number:
      10.1016/j.neuro.2004.09.001
    • Accession Number:
      15713346