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Wando Mount Pleasant Library
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Conditional Silencing of H-2Db Class I Molecule Expression Modulates the Protective and Pathogenic Kinetics of Virus-Antigen-Specific CD8 T Cell Responses during Theiler's Virus Infection.
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- Author(s): Tritz, Zachariah P.1,2; Orozco, Robin C.1,2; Malo, Courtney S.1,2; Ayasoufi, Katayoun2; Fain, Cori E.1,2; Khadka, Roman H.1,2; Goddery, Emma N.1,2; Yokanovich, Lila T.1,2; Settell, Megan L.1; Hansen, Michael J.2; Fang Jin2; Pavelko, Kevin D.2; Pease, Larry R.2,3; Johnson, Aaron J.1,4,5
- Source:
Journal of Immunology. Sep2020, Vol. 205 Issue 5, p1228-1238. 11p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Theiler's murine encephalomyelitis virus (TMEV) infection of the CNS is cleared in C57BL/6 mice by a CD8 T cell response restricted by the MHC class I molecule H-2Db. The identity and function of the APC(s) involved in the priming of this T cell response is (are) poorly defined. To address this gap in knowledge, we developed an H-2Db LoxP-transgenic mouse system using otherwise MHC class I-deficient C57BL/6 mice, thereby conditionally ablating MHC class I-restricted Ag presentation in targeted APC subpopulations. We observed that CD11c+ APCs are critical for early priming of CD8 T cells against the immunodominant TMEV peptide VP2121-130. Loss of H-2Db on CD11c+ APCs mitigates the CD8 T cell response, preventing early viral clearance and immunopathology associated with CD8 T cell activity in the CNS. In contrast, animals with H-2Db-deficient LysM+ APCs retained early priming of Db:VP2121-130 epitope-specific CD8 T cells, although a modest reduction in immune cell entry into the CNS was observed. This work establishes a model enabling the critical dissection of H-2Db-restricted Ag presentation to CD8 T cells, revealing cell-specific and temporal features involved in the generation of CD8 T cell responses. Employing this novel system, we establish CD11c+ cells as pivotal to the establishment of acute antiviral CD8 T cell responses against the TMEV immunodominant epitope VP2121-130, with functional implications both for T cell-mediated viral control and immunopathology. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Immunology is the property of American Association of Immunologists and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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