Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Additional Information
- Source:
Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
- Publication Information:
Publication: Washington Dc : American Chemical Society
Original Publication: [Easton, Pa.] : American Chemical Society, [c1963-
- Subject Terms:
- Abstract:
Analysis of the methanolic extract of Calotropis procera root barks enabled the identification of a novel cardenolide (2''-oxovoruscharin) to be made. Of the 27 compounds that we hemisynthesized, one (23) exhibited a very interesting profile with respect to its hemisynthetic chemical yield, its in vitro antitumor activity, its in vitro inhibitory influence on the Na+/K+-ATPase activity, and its in vivo tolerance. Compound 23 displayed in vitro antitumor activity on a panel of 57 human cancer cell lines similar to taxol, and higher than SN-38 (the active metabolite of irinotecan), two of the most potent drugs used in hospitals to combat cancer.
- Accession Number:
0 (2''-oxovoruscharin)
0 (Antineoplastic Agents)
0 (Cardenolides)
0 (Organoplatinum Compounds)
0 (Thiazoles)
04ZR38536J (Oxaliplatin)
6PLQ3CP4P3 (Etoposide)
7673326042 (Irinotecan)
EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
P88XT4IS4D (Paclitaxel)
XT3Z54Z28A (Camptothecin)
- Publication Date:
Date Created: 20050204 Date Completed: 20050307 Latest Revision: 20220227
- Publication Date:
20240829
- Accession Number:
10.1021/jm049405a
- Accession Number:
15689169
No Comments.