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New answers to the old RIDDLE: RNF168 and the DNA damage response pathway.
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- Author(s): Kelliher, Jessica1 (AUTHOR); Ghosal, Gargi2 (AUTHOR) ; Leung, Justin Wai Chung1 (AUTHOR)
- Source:
FEBS Journal. May2022, Vol. 289 Issue 9, p2467-2480. 14p.- Subject Terms:
- Source:
- Additional Information
- Abstract: The chromatin‐based DNA damage response pathway is tightly orchestrated by histone post‐translational modifications, including histone H2A ubiquitination. Ubiquitination plays an integral role in regulating cellular processes including DNA damage signaling and repair. The ubiquitin E3 ligase RNF168 is essential in assembling a cohort of DNA repair proteins at the damaged chromatin via its enzymatic activity. RNF168 ubiquitinates histone H2A(X) at the N terminus and generates a specific docking scaffold for ubiquitin‐binding motif‐containing proteins. The regulation of RNF168 at damaged chromatin and the mechanistic implication in the recruitment of DNA repair proteins to the damaged sites remain an area of active investigation. Here, we review the function and regulation of RNF168 in the context of ubiquitin‐mediated DNA damage signaling and repair. We will also discuss the unanswered questions that require further investigation and how understanding RNF168 targeting specificity could benefit the therapeutic development for cancer treatment. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of FEBS Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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