Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance.

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  • Additional Information
    • Source:
      Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Print ISSN: 0149-5992 (Print) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
    • Publication Information:
      Publication: Alexandria Va : American Diabetes Association
      Original Publication: New York, American Diabetes Assn.
    • Subject Terms:
      Blood Glucose/*metabolism ; Diabetes Mellitus, Type 2/*blood ; Glucose Intolerance/*blood ; Insulin/*pharmacology ; Insulin-Like Growth Factor I/*metabolism; Biomarkers/blood ; Blood Glucose/drug effects ; Blood Pressure ; Body Mass Index ; Body Size ; Female ; Glucose Tolerance Test ; Humans ; Insulin/blood ; Insulin Resistance ; Lipids/blood ; Male ; Metabolic Syndrome/blood ; Middle Aged ; Reference Values
    • Abstract:
      Objective: We studied the relationships between plasma IGF-I concentrations and insulin sensitivity in subjects with various degrees of glucose tolerance.
      Research Design and Methods: A total of 357 nondiabetic subjects, 54 subjects with impaired glucose tolerance and 98 newly diagnosed type 2 diabetic subjects, were consecutively recruited, and anthropometric and biochemical characteristics were collected.
      Results: IGF-I concentrations were negatively correlated with age, BMI, waist-to-hip ratio, triglyceride levels, and systolic and diastolic blood pressure. IGF-I concentrations were positively correlated with HDL cholesterol and homeostasis model assessment of insulin sensitivity (HOMA-S). The correlations remained significant after adjusting for sex, age, and BMI. Correlations for HOMA-S with these metabolic and anthropometric variables were of a similar degree and direction to those for IGF-I concentrations. Stepwise linear regression analysis in a model, which included well-known modulators of insulin sensitivity such as sex, age, BMI, glucose tolerance status, family history of diabetes, waist-to-hip ratio, systolic and diastolic blood pressure, HDL cholesterol, and triglyceride levels, revealed that IGF-I concentrations were independently associated with insulin sensitivity accounting for 10.8% of its variation (P < 0.0001). IGF-I concentrations were significantly lower in subjects with World Health Organization (WHO)-defined metabolic syndrome compared with subjects without metabolic syndrome (P < 0.0001). Logistic regression analysis showed that each unit increase in log-transformed IGF-I concentrations was associated with a 90.5% reduction in the risk of WHO-defined metabolic syndrome.
      Conclusions: These data indicate that IGF-I has the characteristics to be a marker for the insulin resistance syndrome. This suggests that low IGF-I levels may be a useful marker for identifying subjects at risk for cardiovascular disease.
    • Accession Number:
      0 (Biomarkers)
      0 (Blood Glucose)
      0 (Insulin)
      0 (Lipids)
      67763-96-6 (Insulin-Like Growth Factor I)
    • Publication Date:
      Date Created: 20041224 Date Completed: 20050524 Latest Revision: 20220408
    • Publication Date:
      20240628
    • Accession Number:
      10.2337/diacare.28.1.120
    • Accession Number:
      15616244