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Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance.
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- Author(s): Sesti G;Sesti G; Sciacqua A; Cardellini M; Marini MA; Maio R; Vatrano M; Succurro E; Lauro R; Federici M; Perticone F
- Source:
Diabetes care [Diabetes Care] 2005 Jan; Vol. 28 (1), pp. 120-5.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Print ISSN: 0149-5992 (Print) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
- Publication Information: Publication: Alexandria Va : American Diabetes Association
Original Publication: New York, American Diabetes Assn. - Subject Terms: Blood Glucose/*metabolism ; Diabetes Mellitus, Type 2/*blood ; Glucose Intolerance/*blood ; Insulin/*pharmacology ; Insulin-Like Growth Factor I/*metabolism; Biomarkers/blood ; Blood Glucose/drug effects ; Blood Pressure ; Body Mass Index ; Body Size ; Female ; Glucose Tolerance Test ; Humans ; Insulin/blood ; Insulin Resistance ; Lipids/blood ; Male ; Metabolic Syndrome/blood ; Middle Aged ; Reference Values
- Abstract: Objective: We studied the relationships between plasma IGF-I concentrations and insulin sensitivity in subjects with various degrees of glucose tolerance.
Research Design and Methods: A total of 357 nondiabetic subjects, 54 subjects with impaired glucose tolerance and 98 newly diagnosed type 2 diabetic subjects, were consecutively recruited, and anthropometric and biochemical characteristics were collected.
Results: IGF-I concentrations were negatively correlated with age, BMI, waist-to-hip ratio, triglyceride levels, and systolic and diastolic blood pressure. IGF-I concentrations were positively correlated with HDL cholesterol and homeostasis model assessment of insulin sensitivity (HOMA-S). The correlations remained significant after adjusting for sex, age, and BMI. Correlations for HOMA-S with these metabolic and anthropometric variables were of a similar degree and direction to those for IGF-I concentrations. Stepwise linear regression analysis in a model, which included well-known modulators of insulin sensitivity such as sex, age, BMI, glucose tolerance status, family history of diabetes, waist-to-hip ratio, systolic and diastolic blood pressure, HDL cholesterol, and triglyceride levels, revealed that IGF-I concentrations were independently associated with insulin sensitivity accounting for 10.8% of its variation (P < 0.0001). IGF-I concentrations were significantly lower in subjects with World Health Organization (WHO)-defined metabolic syndrome compared with subjects without metabolic syndrome (P < 0.0001). Logistic regression analysis showed that each unit increase in log-transformed IGF-I concentrations was associated with a 90.5% reduction in the risk of WHO-defined metabolic syndrome.
Conclusions: These data indicate that IGF-I has the characteristics to be a marker for the insulin resistance syndrome. This suggests that low IGF-I levels may be a useful marker for identifying subjects at risk for cardiovascular disease. - Accession Number: 0 (Biomarkers)
0 (Blood Glucose)
0 (Insulin)
0 (Lipids)
67763-96-6 (Insulin-Like Growth Factor I) - Publication Date: Date Created: 20041224 Date Completed: 20050524 Latest Revision: 20220408
- Publication Date: 20240628
- Accession Number: 10.2337/diacare.28.1.120
- Accession Number: 15616244
- Source:
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