Endogenous glucose production in type 2 diabetes: basal and postprandial. Role of diurnal rhythms.

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  • Author(s): Radziuk J;Radziuk J; Pye S
  • Source:
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research [J Investig Med] 2004 Sep; Vol. 52 (6), pp. 379-88.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: England NLM ID: 9501229 Publication Model: Print Cited Medium: Print ISSN: 1081-5589 (Print) Linking ISSN: 10815589 NLM ISO Abbreviation: J Investig Med Subsets: MEDLINE
    • Publication Information:
      Publication: 2023-: [Thousand Oaks] : SAGE Publications
      Original Publication: Thorofare, NJ : Slack, c1994-
    • Subject Terms:
      Circadian Rhythm/*physiology ; Diabetes Mellitus, Type 2/*metabolism ; Glucose/*biosynthesis ; Postprandial Period/*physiology; Humans ; Liver/metabolism ; Metabolic Clearance Rate ; Radioactive Tracers
    • Abstract:
      Glycemia in type 2 diabetes is characterized by a nonsteady but stable diurnal cycle. This leads to morning fasting hyperglycemia. It arises from an underlying circadian pattern in endogenous glucose production because the metabolic clearance rate of glucose is decreased but constant. Therefore, it is important to use appropriate nonsteady tracer methods to measure this rate even under basal conditions. Postprandially, in diabetes, the endogenous glucose production continues to decrease, with only minor deviations from the slope of the basal curve. This suggests a decoupling of endogenous glucose production from the regulatory factors (insulin, glucose) that prevail under normal circumstances. As the duration of diabetes increases, metabolic clearance of glucose continues to deteriorate. This may be partially compensated by a decrease in glucose production. This rate remains, however, inappropriate because its impact on glycemia does not decline.
    • Number of References:
      62
    • Accession Number:
      0 (Radioactive Tracers)
      IY9XDZ35W2 (Glucose)
    • Publication Date:
      Date Created: 20041223 Date Completed: 20050113 Latest Revision: 20160804
    • Publication Date:
      20231215
    • Accession Number:
      10.1136/jim-52-06-32
    • Accession Number:
      15612451