[Short-term effect of nebivolol on the left ventricular diastolic function].

Nebivololün sol ventrikül diyastolik fonksiyonlari üzerine erken dönem etkisi.

Publisher: Aves Yayincilik Country of Publication: Turkey NLM ID: 101095069 Publication Model: Print Cited Medium: Print ISSN: 1302-8723 (Print) Linking ISSN: 13028723 NLM ISO Abbreviation: Anadolu Kardiyol Derg Subsets: MEDLINE

Publication: Aug. 2008- : Findikzade, İstanbul : Aves Yayincilik
Original Publication: Cağaloğlu, İstanbul : Birikim Yayıncılık, [2001-

Antihypertensive Agents/*pharmacology ; Benzopyrans/*pharmacology ; Ethanolamines/*pharmacology ; Hypertension/*drug therapy ; Ventricular Dysfunction, Left/*diagnostic imaging ; Ventricular Function, Left/*drug effects; Adult ; Aged ; Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/therapeutic use ; Benzopyrans/administration & dosage ; Benzopyrans/therapeutic use ; Blood Pressure/drug effects ; Echocardiography, Doppler ; Ethanolamines/administration & dosage ; Ethanolamines/therapeutic use ; Female ; Humans ; Hypertension/pathology ; Male ; Middle Aged ; Nebivolol ; Severity of Illness Index ; Time Factors

Objective: To determine the effects of nebivolol on diastolic functions of the left ventricle in the hypertensive patients in the early treatment period.
Methods: Twenty patients with mild to moderate hypertension taking daily 5 mg of nebivolol were assessed by using Doppler echocardiography before and after 6-week drug treatment period. The results were analyzed with Wilcoxon test and p<0.05 was accepted as statistically significant value.
Results: The arterial blood pressure and heart rate of the patients significantly decreased after 6 weeks of treatment. Statistically significant decrease was found in the peak of A wave velocity, isovolumetric relaxation time, E wave deceleration time and increase in E/A ratio with Doppler echocardiography after 6-week treatment period. No statistically significant difference was observed in the peak velocity of E wave after treatment period.
Conclusion: We found that nebivolol improved left ventricular diastolic function in patients with hypertension in the early term.

0 (Antihypertensive Agents)
0 (Benzopyrans)
0 (Ethanolamines)
030Y90569U (Nebivolol)

Date Created: 20041214 Date Completed: 20050127 Latest Revision: 20161124

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