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Effects of Crocin on CCL2/CCR2 Inflammatory Pathway in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats.
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- Author(s): Sheng, Yanling (AUTHOR); Gong, Xiaowei (AUTHOR); Zhao, Jing (AUTHOR); Liu, Yan (AUTHOR); Yuan, Yadong (AUTHOR)
- Source:
American Journal of Chinese Medicine. 2022, Vol. 50 Issue 1, p241-259. 19p. - Source:
- Additional Information
- Subject Terms: LUNG physiology; BLOOD pressure; COLLAGEN; CYTOKINES; PULMONARY hypertension; INFLAMMATION; ALKALOIDS; ANIMAL experimentation; SYSTOLIC blood pressure; RIGHT heart ventricle; WESTERN immunoblotting; IMMUNOHISTOCHEMISTRY; PULMONARY artery; CELL physiology; CAROTENOIDS; CELLULAR signal transduction; GENE expression; RATS; OXIDATIVE stress; DESCRIPTIVE statistics; INFLAMMATORY mediators; DATA analysis software
- Abstract: Pulmonary arterial hypertension (PAH) is a malignant cardiopulmonary disease, in which pulmonary arterial remodeling is regarded as the prominent pathological feature. So far, the mechanism of PAH is still unclear, so its treatment remains a challenge. However, inflammation plays an important part in the occurrence and progression of PAH. It is well known that crocin has anti-inflammatory properties, so we investigated whether crocin could be a potential drug for the treatment of PAH rat models. Rats injected subcutaneously with monocrotaline (MCT) were treated with crocin via a gastric tube daily for four weeks. The results showed that crocin treatment significantly reduced the right ventricular systolic pressure (RVSP) and mean pulmonary artery pressure (mPAP) in the PAH rat models. Moreover, crocin treatment reduced the proliferation of pulmonary arteriole smooth muscle cells (PASMCs). In addition, crocin treatment not only relieved inflammatory cell infiltration and collagen fiber hyperplasia in the lung and right ventricle, but also decreased the expression of the CCL2/CCR2 inflammatory pathway in the lung of PAH rat models. Furthermore, crocin treatment reduced the inflammatory cytokines and oxidative stress responses. In summary, crocin may play a protective role in MCT-induced PAH rats by alleviating inflammatory response, improving pulmonary arterial remodeling, and preventing PAH. Therefore, crocin as a new treatment for PAH may be quite worthy of consideration. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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