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Wando Mount Pleasant Library
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Village Library
9 a.m. - 1 p.m.
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St. Paul's/Hollywood Library
9 a.m. - 5 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 5 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
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Folly Beach Library
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*open the 2nd and 4th Saturday
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Dorchester Road Library
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John L. Dart Library
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Phone: (843) 805-6930
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Dietary Intake of Fatty Acids and Risk of Pancreatic Cancer: A Case-Control Study.
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- Author(s): Li, Donghui (AUTHOR); Zheng, Jiali (AUTHOR); Hatia, Rikita (AUTHOR); Hassan, Manal (AUTHOR); Daniel, Carrie R (AUTHOR)
- Source:
Journal of Nutrition. Feb2022, Vol. 152 Issue 2, p439-447. 9p. - Source:
- Additional Information
- Subject Terms:
- Abstract:
Background: Epidemiological findings on dietary fat intake and risk of pancreatic cancer (PanC) are inconsistent.Objectives: This study aimed to determine the association between types of dietary fat intake and PanC.Methods: We conducted a hospital-based case-control study in 957 pathologically confirmed PanC cases and 938 cancer-free controls. Cases and controls were frequency matched by age, sex, and race. Dietary information was collected using a self-administered validated FFQ. Unconditional logistic regression models were used to estimate the ORs and 95% CIs of PanC risk by quintiles of fat intake with the lowest quintile as referent and with adjustment for other risk factors and dietary factors.Results: We observed no difference in (median) intake of total fat standardized for energy among cases versus controls. The multivariable-adjusted OR (95% CI) of the highest versus the lowest quintile of intake (ORQ5 compared with Q1) was 2.51 (1.68-3.72) for fat from animal sources and 0.41 (0.29-0.58) for fat from plant sources. Intakes of total MUFA, total PUFA, and linoleic (n-6) and long chain n-3 fatty acids were inversely associated with PanC (ORQ5 compared with Q1 and 95% CI: 0.55 [0.36-0.82], 0.59 [0.42-0.82], 0.64 [0.43-0.84], and 0.60 [0.42-0.84], respectively). Arachidonic acid (n-6) and several SFAs were positively associated with PanC.Conclusion: Although some observed associations with pancreatic cancer risk could be explained by reverse causation, the potential protective associations with intakes of largely plant-derived PUFAs and MUFAs and fish-derived long chain n-3 PUFAs warrant further prospective investigation. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Journal of Nutrition is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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