[Fatal pancytopenia and methotrexate-trimethoprim-sulfamethoxazole interaction].

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  • Author(s): Bartha P;Bartha P; Bron R; Levy Y
  • Source:
    Harefuah [Harefuah] 2004 Jun; Vol. 143 (6), pp. 398-400, 464.
  • Publication Type:
    Case Reports; English Abstract; Journal Article
  • Language:
    Hebrew
  • Additional Information
    • Source:
      Publisher: Israel Medical Association Country of Publication: Israel NLM ID: 0034351 Publication Model: Print Cited Medium: Print ISSN: 0017-7768 (Print) Linking ISSN: 00177768 NLM ISO Abbreviation: Harefuah Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tel Aviv : Israel Medical Association
    • Subject Terms:
      Methotrexate/*adverse effects ; Pancytopenia/*drug therapy ; Sulfamethoxazole/*toxicity; Aged ; Diagnosis, Differential ; Drug Interactions ; Fatal Outcome ; Female ; Humans ; Pancytopenia/complications ; Pancytopenia/diagnosis
    • Abstract:
      Low dose methotrexate [MTX] is now frequently used for various inflammatory diseases. This is a case study of a fatal outcome in a patient with rheumatoid arthritis [RA] treated for a short period with low dose MTX. The patient developed severe pancytopenia followed by bacterial and monilial sepsis upon the co-administration of trimethoprim-sulphamethoxazole [TMP-SMX] for an intercurrent infection. The differential diagnosis of pancytopenia and the mechanisms underlying the increase in plasma free MTX by MTX-SMX in the patient are discussed. It should be noted that this fatal case highlights the risk of severe drug interactions in patients with multiple risk factors treated with low dose MTX for a short period of time.
    • Accession Number:
      JE42381TNV (Sulfamethoxazole)
      YL5FZ2Y5U1 (Methotrexate)
    • Publication Date:
      Date Created: 20041105 Date Completed: 20041209 Latest Revision: 20131121
    • Publication Date:
      20231215
    • Accession Number:
      15524092