A Rare Cause of Hematuria in Children: Ebstein-Barr Virus. (English)

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    • Alternate Title:
      Çocuklarda Hematürinin Nadir Bir Nedeni: Ebstein-Barr Virus. (Turkish)
    • Abstract:
      A 16.5-year-old male was admitted to the emergency department with fever, sore throat and hematuria. The patient’s body temperature was measured as 40oC, there was no edema and his blood pressure was normal. Oropharynx was hyperemic, there was jaundice on the skin and sclera, hepatosplenomegaly, and multiple lymph nodes up to 4 cm in both cervical chains. Laboratory studies revealed prominent lymphomonocytosis and Downey cells in peripheral blood smear. Liver enzymes and bilirubin levels were elevated, kidney functions were normal. Urinary examination revealed hematuria and non-nephrotic proteinuria. His urinary outflow was normal in follow up. Ultrasonography showed hepatosplenomegaly and an increase in renal parenchymal echogenicities. Epstein-Barr Virus viral capsid antigen immunoglobulin M was positive, polymerase chain reaction result was positive with 140.000 copies/μL. In the follow-up, steroid treatment was given due to persistent fever and rapid growth in lymph nodes, and then the fever did not recur. Macroscopic hematuria improved on the fourth day of his hospitalization, and at the third week of control, hematuria and proteinuria disappeared completely. [ABSTRACT FROM AUTHOR]
    • Abstract:
      16.5 yaşındaki erkek hasta ateş, boğaz ağrısı ve kanlı idrar yapma şikayeti ile acile başvurdu. Vücut ısısı 40oC ölçülen hastanın ödemi yoktu ve kan basıncı normaldi. Fizik muayenesinde orofarenksi hiperemik, ciltte ve sklerada ikter, hepatosplenomegali ve her iki servikal zincirde 4 cm’yi bulan birden fazla lenf nodu saptandı. Laboratuvar tetkiklerinde belirgin lenfomonositozu ve periferik yaymada Downey hücreleri görüldü. Karaciğer enzimleri ve bilirubin seviyeleri yüksekti, böbrek fonksiyonları normaldi. İdrar tetkikinde hematüri ve nefrotik düzeyde olmayan proteinüri mevcuttu. Kolestatik hepatit ve glomerulonefrit ön tanıları ile izlenen hastanın izleminde idrar çıkışı normal seyretti. Ultrasonografide hepatosplenomegali ve böbreklerin parankim ekojenitesi artmıştı. Epstein-Barr virüs viral kapsit antijen immunglobulin M pozitif geldi ve polimeraz zincir reaksiyonu ile Epstein-Barr virüs, 140.000 kopya/μL bulundu. İzleminde direngen ateşi devam etmesi ve lenf nodlarında hızlı büyüme nedeni ile steroid tedavisi verildi, sonrasında ateşi tekrarlamadı. Yatışının dördüncü gününde makroskopik hematürisi düzelen hastanın üçüncü haftaki kontrolünde hematüri ve proteinürinin tamamen kaybolduğu görüldü. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Pediatric Infection / Çocuk Enfeksiyon Dergisi is the property of Journal of Pediatric Infection / Cocuk Enfeksiyon Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)