Methandienone contributes directly on develop central serous chorioretinopathy in athletes.

No studies have investigated the increases of level of s. cortisol and s. testosterone during exogenous androgen intake and its role in (CSCR) in individual athletes. Methods: In current research, we recruited 90 people divided into 60 players of athletes (CSCR patients) and 30 regular control people. All patients underwent a full ophthalmic test. After taking a detailed medical history, both patients received 50 mg of Methandienone per day for months and 50 mg per day for months. Serum levels of cortisol and total testosterone were calculated using the automated access 2 immunoassay method in compliance with the manufacturer's protocol (Beckman Coulter). Results: There is a substantial difference in certain Anthropometrics (p<0.01) in the present sample, namely, ASUA, education, residency, weight, jobs, PSS, body muscle content (percent), body fat content (percent), serum cortisol and serum testosterone. There is a difference in significance (p<0.01) between patients and controls with PSS, serum cortisol and serum testosterone in the comparison control sample, and patients after subdividing the latter into three subgroups according to their job of delineating high stress groups with the help of PSS. Conclusion: In conclusion, the inference that the ophthalmologist remains a danger to CSCR may be rational, Based on the results of our study, we strongly believe that CSCR is induced by the intake of methandienone, which shares a direct link with stress and high levels of cortisol and low levels of testosterone through feedback inhibition, and that this connection will be essential to establish in future large-scale studies that could help prevent and treat disease. [ABSTRACT FROM AUTHOR]

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