Uloga vitamina D u neurološkim bolestima. (Croatian)

The role of vitamin D in neurologic diseases. (English)

Vitamin D is an essential nutrient necessary for the homeostasis of calcium and health of the skeletal system, with an increasing role in neurological diseases. All factors of vitamin D metabolism are present in the central nervous system, with autocrine and paracrine mechanisms of action. Vitamin D affects the levels of neurotrophic factors, regulates immune function and nervous system homeostasis. Vitamin D levels and supplementation is the subject of researches in most neurodegenerative diseases, with the lack associated with an increased disease risk. Researches in the field are promising, but there is a lack of high-quality studies needed for guidelines. [ABSTRACT FROM AUTHOR]

Vitamin D nužan je nutrijent potreban za homeostazu kalcija i zdravlje koštanog sustava, no sve se češće potvrđuje njegova uloga u neurološkim bolestima. U središnjem živčanom sustavu prisutni su svi čimbenici metabolizma vitamina D te je djelovanje moguće parakrinim i autokrinim putem. Vitamin D utječe na razine neurotrofnih čimbenika, regulaciju imunološke funkcije te na homeostazu središnjeg živčanog sustava. Manjak vitamina D i njegova nadoknada predmet je istraživanja većine neurodegenerativnih bolesti te je manjak povezan s povećanim rizikom nastanka bolesti. Dosadašnja su istraživanja nadoknađivanja vitamina D obećavajuća, no postoji nedostatak visokokvalitetnih studija za čvrste dokaze i smjernice. [ABSTRACT FROM AUTHOR]

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