Association of serum apolipoprotein C III levels and apolipoprotein C III gene Sst I polymorphism with carotid intima-media thickness in Chinese type 2 diabetic patients.

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  • Author(s): Chen X;Chen X; Tian H; Liu R
  • Source:
    Diabetes research and clinical practice [Diabetes Res Clin Pract] 2004 Oct; Vol. 66 (1), pp. 41-7.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8508335 Publication Model: Print Cited Medium: Print ISSN: 0168-8227 (Print) Linking ISSN: 01688227 NLM ISO Abbreviation: Diabetes Res Clin Pract Subsets: MEDLINE
    • Publication Information:
      Publication: 1993- : Limerick : Elsevier Scientific Publishers
      Original Publication: Amsterdam : Elsevier Science Publishers B.V., c1985-
    • Subject Terms:
      Polymorphism, Genetic*; Apolipoproteins C/*genetics ; Diabetes Mellitus, Type 2/*genetics ; Tunica Intima/*pathology ; Tunica Media/*pathology; Apolipoprotein C-III ; Apolipoproteins C/blood ; Blood Glucose/metabolism ; Carotid Arteries/pathology ; Carotid Stenosis/blood ; Carotid Stenosis/genetics ; Carotid Stenosis/pathology ; China ; Deoxyribonucleases, Type II Site-Specific ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/pathology ; Diabetic Angiopathies/blood ; Diabetic Angiopathies/genetics ; Diabetic Angiopathies/pathology ; Humans ; Insulin/blood ; Lipids/blood ; Middle Aged ; Risk Factors
    • Abstract:
      Apolipoprotein C III (apo C III) plays a central role in regulating plasma metabolism of triglyceride-rich lipoprotein (TRL). The G3238C allele (Sst I) in the 3'-untranslated region has been found to be associated with raised apo C III levels and hypertriglyceridemia (HTG). Some studies suggest that apo C III and the S(2) allele of apo C III gene are independent risk factors for atherosclerotic diseases. To study the potential association between these factors we analyzed the clinical data and their correlations with serum apo C III levels, apo C III gene Sst I polymorphism, and carotid intima-media thickness (IMT) in 78 unrelated Chinese patients with type 2 diabetes. Apo C III gene Sst I polymorphism was examined using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Carotid IMT was measured by color doppler ultrasound examination. Serum apo C III levels were found to be positively associated with plasma TG ( r = 0.527, P < 0.001), TC (r = 0.424, P < 0.001), LDL-C (r = 0.308, P < 0.01) concentrations, and carotid IMT (r =0.359, P < 0.01 ). Multivariate analysis (backward) showed that diastolic blood pressure, apo C III, and fasting insulin levels were independent risk factors of carotid IMT. However, the results did not show the association between S(2) allele and carotid IMT in our diabetic patients. Thus, our study suggested that apo C III is an independent risk factor for atherosclerotic diseases in Chinese type 2 diabetes.
    • Accession Number:
      0 (Apolipoprotein C-III)
      0 (Apolipoproteins C)
      0 (Blood Glucose)
      0 (Insulin)
      0 (Lipids)
      EC 3.1.21.- (endodeoxyribonuclease SacI)
      EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
    • Publication Date:
      Date Created: 20040915 Date Completed: 20050412 Latest Revision: 20111117
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.diabres.2004.02.020
    • Accession Number:
      15364160