Auditory neuropathy in hyperbilirubinemia: is there a correlation between serum bilirubin, neuron-specific enolase levels and auditory neuropathy?

Neuropatía auditiva en la hiperbilirrubinemia: ¿existe una correlación entre bilirrubina sérica, niveles neurona-especificos de enolasa y neuropatía auditiva?

HYPERBILIRUBINEMIA; ENOLASE; NEUROPATHY; EVOKED response audiometry; OTOACOUSTIC emissions; PATIENTS

This study evaluated whether a correlation exists between increased serum bilirubin and neuron-specific enolase (NSE) assays (a biochemical index of neuronal damage) and auditory neuropathy. Nineteen term neonates without hemolysis whose serum bilirubin levels were above 20 mg/dl and 27 healthy term newborns with bilirubin levels < 13 mg/dl were included in the study. Auditory brainstem responses (ABRs) and transient evoked oto-acoustic emissions (TEOAEs) of patients with hyperbilirubinemia were obtained before discharge. This preliminary study did not show any correlation between the serum NSE and bilirubin values. However, infants who had auditory neuropathy had significantly higher NSE levels, and thus these patients, being in the high-risk group, need close follow-up. [ABSTRACT FROM AUTHOR]

Este estudío evalúa cuándo existe una correlación entre la bilirrubina sérica aumentada y los niveles neuronaespecificos de enolasa (NSE) (un indice bioquimico de daño neuronal) con la neuropatia auditiva. Diez y nueve neonatos a término sin hemólisis, cuya bilirrubina sérica estuvo por arriba de 20 mg/dl y 27 neonatos de término sanos, con niveles de bilirrubina de < 13 mg/dl, se incluyeron en este estudio. Las respuestas auditivas del tallo cerebral (ABRs) y las emisiones otoacústicas evocadas por transitorios (TEOAEs) de los pacientes con hiperbilirrubinemia se obtuvieron después del alta hospitalaria. Este estudio preliminar no mostró ninguna correlación entre la NSE en suero y los valores de bilirrubina. No obstante, los niños que tuvieron neuropatia auditiva presentaron niveles NSE significativamente mayores por lo que esos pacientes, estando en el grupo de alto riesgo, requieren un seguimiento más cercano. [ABSTRACT FROM AUTHOR]

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