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Edgar Allan Poe/Sullivan's Island Library
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West Ashley Library
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Wando Mount Pleasant Library
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Differential Patterns of Delayed Emotion Circuit Maturation in Abused Girls With and Without Internalizing Psychopathology.
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- Author(s): Keding, Taylor J.; Heyn, Sara A.; Russell, Justin D.; Zhu, Xiaojin; Cisler, Josh; McLaughlin, Katie A.; Herringa, Ryan J.
- Source:
American Journal of Psychiatry; Nov2021, Vol. 178 Issue 11, p1026-1036, 11p- Subject Terms:
EMOTIONS; AGE; NEURAL circuitry; INSULAR cortex; GRAY matter (Nerve tissue); CHILD psychopathology; ADOLESCENT psychopathology; POST-traumatic stress disorder; PREVENTION of child abuse; CHILD abuse & psychology; MENTAL depression; DIAGNOSIS of post-traumatic stress disorder; DIAGNOSIS of mental depression; BRAIN; RESEARCH; CHILD development; ANTHROPOMETRY; RESEARCH methodology; MAGNETIC resonance imaging; MEDICAL cooperation; EVALUATION research; LANGUAGE acquisition; COMPARATIVE studies; PATHOLOGICAL psychology; RESEARCH funding; ANXIETY disorders; PSYCHOLOGICAL resilience; PSYCHOLOGICAL factors - Source:
- Additional Information
- Abstract:
Objective: Childhood abuse represents one of the most potent risk factors for developing psychopathology, especially in females. Evidence suggests that exposure to early-life adversity may be related to advanced maturation of emotion processing neural circuits. However, it remains unknown whether abuse is related to early circuit maturation and whether maturation patterns depend on the presence of psychopathology.Methods: A multisite sample of 234 girls (ages 8-18 years) completed clinical assessment, maltreatment histories, and high-resolution T1-weighted structural MRI. Girls were stratified by abuse history and internalizing disorder diagnosis into typically developing (no abuse/no diagnosis), resilient (abuse/no diagnosis), and susceptible (abuse/current diagnosis) groups. Machine learning models of normative brain development were aggregated in a stacked generalization framework trained to predict chronological age using gray matter volume in whole-brain, emotion, and language circuit parcellations. Brain age gap estimations (BrainAGEs; predicted age minus true chronological age) were calculated as indices of relative circuit maturation.Results: Childhood abuse was related to reduced BrainAGE (delayed maturation) specific to emotion circuits. Delayed emotion circuit BrainAGE was further related to increased hyperarousal symptoms. Childhood physical neglect was associated with increased whole-brain BrainAGE (advanced maturation). Neural contributors to emotion circuit BrainAGE differed in girls with and without an internalizing diagnosis, especially in the lateral prefrontal, parietal, and insular cortices and the hippocampus.Conclusions: Abuse exposure in girls is associated with a delayed structural maturation pattern specific to emotion circuitry, a potentially adaptive mechanism enhancing threat generalization. Physical neglect, on the other hand, is associated with a broader brain-wide pattern of advanced structural maturation. The differential influence of fronto-parietal cortices and the hippocampus on emotion circuit maturity in resilient girls may represent neurodevelopmental markers of reduced psychiatric risk following abuse. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of American Journal of Psychiatry is the property of American Psychiatric Publishing, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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