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West Ashley Library
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Phone: (843) 766-6635
Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
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Otranto Road Library
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McClellanville Library
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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Phone: (843) 805-6930
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Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Yang, Xiuxiu (AUTHOR); Guo, Yaxin (AUTHOR); Chen, Chen (AUTHOR); Shao, Bo (AUTHOR); Zhao, Luyang (AUTHOR); Zhou, Quanbo (AUTHOR); Liu, Jinbo (AUTHOR); Wang, Guixian (AUTHOR); Yuan, Weitang (AUTHOR); Sun, Zhenqiang (AUTHOR)
- Source:
Immunology. Nov2021, Vol. 164 Issue 3, p476-493. 18p. - Source:
- Additional Information
- Subject Terms:
- Abstract: In recent years, an increasing number of studies have reported that intestinal microbiota have an important effect on tumour immunity by affecting the tumour microenvironment (TME). The intestinal microbiota are closely associated with various immune cells, such as T lymphocytes, natural killer cells (NK cells) and macrophages. Some bacteria, such as Akkermansia muciniphila (A. muciniphila) and Lactobacillus reuteri (L. reuteri), have been shown to improve the effect of tumour immunity. Furthermore, microbial imbalance, such as the increased abundance of Fusobacterium nucleatum (F. nucleatum) and Helicobacter hepaticus (H. hepaticus), generally causes tumour formation and progression. In addition, some microbiota also play important roles in tumour immunotherapy, especially PD‐L1‐related therapies. Therefore, what is the relationship between these processes and how do they affect each other? In this review, we summarize the interactions and corresponding mechanisms among the intestinal microbiota, immune system and TME to facilitate the research and development of new targeted drugs and provide new approaches to tumour therapy. [ABSTRACT FROM AUTHOR]
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