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9 a.m. - 4 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
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Village Library
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Phone: (843) 884-9741
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Phone: (843) 889-3300
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
A Six-Gene Prognostic Risk Prediction Model In Hepatitis B Virus-Associated Hepatocellular Carcinoma.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Jia Shen; Ming Shu; Shujie Xie; Jia Yan; Kaile Pan; Shuhuai Chen; Xiang Li; Shen, Jia (AUTHOR); Shu, Ming (AUTHOR); Xie, Shujie (AUTHOR); Yan, Jia (AUTHOR); Pan, Kaile (AUTHOR); Chen, Shuhuai (AUTHOR); Li, Xiang (AUTHOR)
- Source:
Clinical & Investigative Medicine. Sep2021, Vol. 44 Issue 3, pE32-E44. 13p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Purpose: This study aimed to screen hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC)-related feature ribonucleic acids (RNAs) and to establish a prognostic model. Methods: The transcriptome expression data of HBV-associated HCC were downloaded from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus database. Differential RNAs between HBV-associated HCC and normal controls were identified by a meta-analysis of TCGA, GSE55092 and GSE121248. Weighted gene co-expression network analysis was performed to identify key RNAs and modules. A prognostic score model was established using TCGA as a training set by Cox regression analysis and was validated in E-TABM-36 dataset. Additionally, independent prognostic clinical factors were screened, and the function of lncRNAs was predicted through Gene Set Enrichment Analysis. Results: A total of 710 consistent differential RNAs between HBV-associated HCC and normal controls were obtained, including five lncRNAs and 705 mRNAs. An optimized combination of six differential RNAs (DSCR4, DBH, ECM1, GDAP1, MATR3 and RFC4) was selected and a prognostic score model was constructed. Kaplan-Meier analysis demonstrated that the prognosis of the high-risk and low-risk groups separated by this model was significantly different in the training set and the validation set. Gene Set Enrichment Analysis showed that the co-expression genes of DSCR4 were significantly correlated with neuroactive ligand receptor interaction pathway. Conclusion: A prognostic model based on DSCR4, DBH, ECM1, GDAP1, MATR3 and RFC4 was developed that can accurately predict the prognosis of patients with HBV-associated HCC. These genes, as well as histologic grade, may serve as independent prognostic factors in HBV-associated HCC. [ABSTRACT FROM AUTHOR]
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