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Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
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McClellanville Library
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Phone: (843) 805-6930
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Clinical characteristics and prognostic factors of acquired haemophilia A in Korea.
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- Author(s): Hyun, Shin Young (AUTHOR); Shin, Ho‐Jin (AUTHOR); Yoon, Sung‐Soo (AUTHOR); Moon, Joon Ho (AUTHOR); Han, Jae Joon (AUTHOR); Yang, Deok‐Hwan (AUTHOR); Lee, Won Sik (AUTHOR); Bang, Soo‐Mee (AUTHOR); Yhim, Ho‐Young (AUTHOR); Kim, Sung‐Hyun (AUTHOR); Oh, Doyeun (AUTHOR); Do, Young Rok (AUTHOR); Park, Yong (AUTHOR); Choi, Chul Won (AUTHOR); Lee, Je‐Hwan (AUTHOR); Jang, Ji Eun (AUTHOR); Kim, Soo‐Jeong (AUTHOR); Hwang, Doh Yu (AUTHOR); Kim, Jin Seok (AUTHOR)
- Source:
Haemophilia. Sep2021, Vol. 27 Issue 5, pe609-e616. 8p. 1 Diagram, 5 Charts, 2 Graphs. - Source:
- Additional Information
- Subject Terms:
- Subject Terms:
- Abstract: Introduction: Acquired haemophilia A (AHA) treatment involves the haemostatic treatment for acute haemorrhage and immunosuppressive therapy (IST) to eradicate FVIII inhibitory antibodies. Aim: We assessed the clinical features of AHA and analysed treatment outcomes in Korea. We further identified prognostic factors affecting treatment outcomes. Methods: Medical records of 55 patients with AHA from 18 institutions were reviewed retrospectively. Logistic and Cox regression analyses were performed to elucidate clinical factors affecting the achievement of complete remission (CR). The primary endpoint was time to CR after IST, and secondary endpoints were time to haemostasis, the achievement of CR, and overall survival (OS). Results: Among the 55 patients, 50 (91%) had bleeding symptoms. Bleeding was severe in 74% of patients. Thirty‐six (72%) patients received haemostatic therapy. Of the 42 patients who received IST, 23 (52%) received steroid alone, with a 52% response rate, and 10 (25%) received a combination of steroid and cyclophosphamide, with an 83% response rate. Five (16%) patients relapsed after a median duration of 220 days. There were eight deaths. In the Cox regression analysis, the FVIII inhibitor titre ≥ 20 BU/mL was the only significant prognostic factor affecting time to CR and haemostasis. No significant difference was observed in OS based on the inhibitor titre. Conclusion: The present study demonstrated the demographic data of AHA in Korea and showed that FVIII inhibitory antibody titre was a predictor of time to achieve CR after IST. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Haemophilia is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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