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Engineering cartilage graft using mesenchymal stem cell laden polyacrylamide-galactoxyloglucan hydrogel for transplantation.
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- Author(s): Gopalakrishnan Usha, Preethi; Jalajakumari, Sreekutty; Sheela, Unnikrishnan Babukuttan; Mohan, Deepa; Berry, Catherine; Tripathi, Anuj; Thankappan Nair, Sreelekha T
- Source:
Journal of Biomaterials Applications; Sep2021, Vol. 36 Issue 3, p541-551, 11p
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- Abstract:
Hydrogels are reported to have various biomedical field applications, and many reports also suggest that soft gels promote stem cell differentiation. Chondrogenic differentiation of mesenchymal stem cells (MSC) is significant in articular cartilage repair. This study focuses on polysaccharide-based hydrogels which enhance chondrocyte lineage differentiation of MSC when grown in the hydrogels. This study implies that the prepared hydrogels promote specific lineage without any external chemical induction factors. The techniques, including immunofluorescence and functional assays to assess the differentiation and in vivo implantation, were employed. All observations paved the way towards confirmation that the galactoxyloglucan-based hydrogel is an attractive candidate for supporting stem cell growth and cartilaginous differentiation. [ABSTRACT FROM AUTHOR]
- Abstract:
Copyright of Journal of Biomaterials Applications is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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