Synthetic approaches for cyclohexane-1,3-diones: A versatile precursor for bioactive molecules.

Cyclohexane-1,3-dione derivatives are considered as a key structural precursor for the synthesis of plethora of synthetically significant compounds such as 4H-chromenones, 2H-xanthenones, coumarins, enaminones, acridinedione, 1,4-dihydropyridine, different other heterocycles, and natural products. These compounds show the diverse range of biological activities that include herbicidal, pesticidal, anti-bacterial, anti-inflammatory, anti-tumor, analgesic, anti-convulsant, anti-viral, anti-plasmodial, anti-malarial, anti-allergic, anti-cancer, etc. This versatility in the chemistry of cyclohexan-1,3-dione and its derivatives is due to the presence of highly active methylene moiety and its active di-carbonyl groups. There are only few reviews in the literature published on the synthetic application of cyclohexane-1,3-diones, but not on the synthesis of cyclohexane-1,3-dione and its derivatives. Keeping the importance of cyclohexane-1,3-dione derivatives in view, we inspired to do a compilation of their synthetic methods from different precursors, which are mainly published in last two decades. [ABSTRACT FROM AUTHOR]

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