[Nitric oxide--a potential modulator of left ventricular diastolic function in hemodialysis patients treated with erythropoietin].

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  • Additional Information
    • Transliterated Title:
      Dusicni oksid--potencijalni modulator dijastolne funkcije lijeve srcane komore u hemodijaliznih pacijenata tretiranih eritropoetinom.
    • Source:
      Publisher: Drustvo Ljekara Bosne I Hercegovine Country of Publication: Bosnia and Herzegovina NLM ID: 0400722 Publication Model: Print Cited Medium: Print Linking ISSN: 0350199X NLM ISO Abbreviation: Med Arh Subsets: MEDLINE
    • Publication Information:
      Original Publication: Sarajevo : Drustvo Ljekara Bosne I Hercegovine
    • Subject Terms:
      Renal Dialysis*; Erythropoietin/*therapeutic use ; Hypertrophy, Left Ventricular/*physiopathology ; Nitric Oxide/*physiology ; Ventricular Function, Left/*physiology; Adult ; Anemia/drug therapy ; Anemia/etiology ; Diastole ; Echocardiography, Doppler, Pulsed ; Humans ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/etiology ; Nitric Oxide/blood ; Recombinant Proteins
    • Abstract:
      Unlabelled: Left ventricular hypertrophy (LVH) is commonly present in hemodialysis patients (HD pts) and is considered as an independent risk factor for high mortality. Many studies have confirmed sound connection between anemia and LVH in this patients.
      Objective: To analyse dystolic function of LVH in uraemic pts during the 6 months human recombinant erythropoectin (rHu-Epo) treatment of anemia, with emphasis on the role of nitric oxide (NO), whose role in regulation of LV diastolic distensibility has been hinted in some recent studies.
      Patients and Methods: The study included 20 HD pts, aged 39.6 +/- 5.3 yrs, with the same condition of HD treatment, signs of anemia and echocardiographically verified LVH. Pulse Doppler echocardiography confirmed LV diastolic function as a ratio of early to late diastolic mitral flow velocity (E/A). Nitrate concentration was determined by colorimetric method using Greiss reagent. Renal anemia was treated with rHuEpo.
      Results: Six months rHuEpo treatment of anemia in HD pts with LVH caused significant reduction of LV mass index (p = 0.008). However, we observed unfavourable fall in LV diastolic function (E/A = 0.83, p = 0.007). In the same time, it was found that the serum NO level was higher for 11.8% in HD pts with LVH as compared with the pts with normal LV mass. Also, the significant positive correlation was found between the level of NO and LV mass index before (p = 0.004) and after rHuEpo therapy (p = 0.03), as well as a significant positive correlation between NO and E/A in the same conditions (p = 0.002) and p = 0.049). Level of NO negatively correlates with blood hemoglobin level, but without statistical significance.
      Conclusions: Correction of anemia with rHuEpo leads to the significant partial regression of LVH. Reduction of diastolic function of LV, observed after diminished LV mass index, could be related to the significant fall of NO level and damaged response of LV to NO. The results of the study strongy suggest that NO can present an important determinant of LV diastolic function in uraemic pts.
    • Accession Number:
      0 (Recombinant Proteins)
      11096-26-7 (Erythropoietin)
      31C4KY9ESH (Nitric Oxide)
    • Publication Date:
      Date Created: 20040619 Date Completed: 20040729 Latest Revision: 20161124
    • Publication Date:
      20231215
    • Accession Number:
      15202319