Accuracy of dipyridamole myocardial contrast echocardiography for the detection of residual stenosis of the infarct-related artery and multivessel disease early after acute myocardial infarction.

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  • Author(s): Janardhanan R;Janardhanan R; Senior R
  • Source:
    Journal of the American College of Cardiology [J Am Coll Cardiol] 2004 Jun 16; Vol. 43 (12), pp. 2247-52.
  • Publication Type:
    Comparative Study; Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print Cited Medium: Print ISSN: 0735-1097 (Print) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
    • Publication Information:
      Original Publication: [New York, N.Y.] : Elsevier Biomedical, [c1983-
    • Subject Terms:
      Dipyridamole* ; Echocardiography* ; Vasodilator Agents*; Coronary Stenosis/*diagnosis ; Coronary Vessels/*diagnostic imaging ; Coronary Vessels/*pathology ; Myocardial Infarction/*diagnosis; Aged ; Coronary Angiography ; Coronary Circulation/physiology ; Coronary Stenosis/epidemiology ; Coronary Stenosis/physiopathology ; Coronary Vessels/physiopathology ; False Positive Reactions ; Female ; Humans ; Image Enhancement ; Male ; Middle Aged ; Myocardial Infarction/epidemiology ; Myocardial Infarction/physiopathology ; Observer Variation ; Sensitivity and Specificity ; Time Factors
    • Abstract:
      Objectives: We aimed to evaluate the ability of vasodilator myocardial contrast echocardiography (MCE) to detect significant infarct-related artery (IRA) stenosis and multivessel disease (MVD) after thrombolysis.
      Background: The detection of residual IRA stenosis subtending significant viable myocardium and the identification of MVD may help to triage patients who may benefit from mechanical revascularization after acute myocardial infarction (AMI) and thrombolysis.
      Methods: Patients with AMI underwent low-power MCE at rest and after dipyridamole stress during SonoVue infusion seven to 10 days after thrombolysis.
      Results: Of the 73 patients, 61 demonstrated significant myocardial viability, of whom 57 (93%) showed significant IRA stenosis. Sensitivities to detect >50% IRA stenosis and MVD were 88% and 72%, respectively. The accuracy of detecting significant coronary stenosis in the anterior (left anterior descending coronary artery) versus inferoposterior (right coronary artery/left circumflex artery) circulation was similar for both IRA (85% vs. 91%) and remote territories (91% vs. 81%). Quantitative peak contrast intensity (p = 0.02), microbubble velocity (p = 0.0001), and myocardial blood flow (p < 0.0001) were significantly lower in patients with significant coronary stenosis during dipyridamole compared with rest. Only beta reserve discriminated various grades of coronary stenosis.
      Conclusions: Use of MCE accurately predicted significant IRA stenosis and MVD after thrombolysis. This information is valuable for identifying patients who may benefit from mechanical revascularization.
    • Accession Number:
      0 (Vasodilator Agents)
      64ALC7F90C (Dipyridamole)
    • Publication Date:
      Date Created: 20040615 Date Completed: 20040723 Latest Revision: 20191210
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.jacc.2004.02.050
    • Accession Number:
      15193688