Clinical presentation of a stroke-like episode in MELAS syndrome: what is the impact of epileptogenic activity?

MELAS syndrome; EPILEPSY; BEHAVIOR disorders; MENTAL illness; SPATIAL orientation; COGNITION disorders; PROGNOSIS

Although this consideration did not justify, in our opinion, the use of AEDs without seizures or EEG abnormalities as proposed by some authors [[3]], however, it supports the epileptogenic hypothesis of explaining part of specific related symptoms in stroke-like lesions. However, some authors suggest LAC as an adjunctive therapy in the treatment of seizures in patients with MELAS [[6]], considering its safe profile. Here, we report a case of a 10-year-old girl with no significant past medical or family history, who presented an agitation state with aggressive behaviour, flattened affect, irritability and an underhand cognitive impairment. [Extracted from the article]

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