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HER2-targeted therapies in gastric cancer.
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- Author(s): Zhu, Yinxing1 (AUTHOR); Zhu, Xuedan1 (AUTHOR); Wei, Xiaowei1 (AUTHOR); Tang, Cuiju1 (AUTHOR) ; Zhang, Wenwen1 (AUTHOR)
- Source:
BBA - Reviews on Cancer. Aug2021, Vol. 1876 Issue 1, pN.PAG-N.PAG. 1p.- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Molecular targeted therapy of cancer has always been the focus of clinicians. Among those therapeutic targets, the human epidermal growth factor receptor-2 (HER-2) signaling pathway is one of the most popular targets for translational research in cancer. However, unlike prospect in breast cancer, HER-2 inhibitor trastuzumab is the only molecular targeted drug approved by US Food and Drug Administration (FDA) for the first-line treatment of HER-2 positive advanced gastric cancer. On this basis, a variety of novel HER2- targeted drugs for gastric cancer are under development, and related clinical researches are in full swing, including small molecular kinase inhibitors (e.g., afatinib, neratinib, pyrotinib), antibody-drug conjugates (e.g., DS-8201a, RC48-ADC) and other novel therapies (e.g., ZW25, CAR-T, BVAC-B). In this study, we will summarize the recent advances in anti-HER-2 agents, potential mechanisms of resistance to HER2-targeted therapy in HER2-positive gastric cancer. We will also discuss the future prospects of potential strategies to overcome anti-HER-2 resistance and development of novel anti-HER-2 approaches for the treatment of HER2-positive gastric cancer patients. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of BBA - Reviews on Cancer is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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