Angelica dahurica and Rheum officinale Facilitated Diabetic Wound Healing by Elevating Vascular Endothelial Growth Factor.

DIABETES complications; BLOOD sugar analysis; THERAPEUTIC use of plant extracts; WOUND healing; TRAUMATOLOGY diagnosis; STATISTICS; CYTOKINES; BIOPSY; STAINS & staining (Microscopy); BODY weight; ANIMAL experimentation; IMMUNOHISTOCHEMISTRY; RATS; DESCRIPTIVE statistics; TUMOR necrosis factors; WOUNDS & injuries; PLANT extracts; VASCULAR endothelial growth factors; DATA analysis software; DATA analysis; CHINESE medicine

Traditional Chinese medicine (TCM) provides alternative treatment choices for diabetic wounds. The aim of this study was to evaluate the effects of Angelica dahurica and Rheum officinale (ARE) on diabetic wounds and its underlying action mechanism. A total of 36 healthy male Sprague–Dawley rats were randomly divided into three groups: diabetes mellitus (DM) rats treated with ARE (DM-ARE), DM rats treated with 0.9% saline (DM-NS), and non-DM rats treated with 0.9% saline (NDM-NS). DM was induced by intraperitoneal administration of 40 mg/kg of streptozotocin after a 2-week high-fat diet feeding. After excisional skin wounds and treatments, the remaining wound area (RWA) in each group was measured. The RWA in the DM-NS group (69.60% ± 2.35%) was greater than that in the DM-ARE (55.70% ± 1.85%) and NDM-NS groups (52.50% ± 2.77%) on day 6. Besides, the DM-ARE group showed higher vascular endothelial growth factor (VEGF), higher inducible nitric oxide synthase (iNOs), higher α -smooth muscle actin (α -SMA), and lower nuclear factor kappa-light-chain-enhancer of activated B cell (NF- κ B) expression in the wound skin tissue. These results showed that treatment with ARE shifted the recovery pattern of diabetic rats to the pattern of nondiabetic rats, indicating that ARE may improve wound healing in diabetic conditions. [ABSTRACT FROM AUTHOR]

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