[In vitro reactivation of acetylcholinesterase inhibition by O-isopropylmethylfluorophosphonate using the bisquarternary oxime, HS-6].

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  • Author(s): Kuca K;Kuca K; Cabal J
  • Source:
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti [Ceska Slov Farm] 2004 Mar; Vol. 53 (2), pp. 93-5.
  • Publication Type:
    English Abstract; Journal Article
  • Language:
    Czech
  • Additional Information
    • Transliterated Title:
      In vitro reaktivace acetylcholinesterázy inhibované O-isopropylmethylfluorofosfonátem uzitím biskvarterního oximu HS-6.
    • Source:
      Publisher: Ceská lékarská spolecnost J. E. Purkyne Country of Publication: Czech Republic NLM ID: 9433765 Publication Model: Print Cited Medium: Print ISSN: 1210-7816 (Print) Linking ISSN: 12107816 NLM ISO Abbreviation: Ceska Slov Farm Subsets: MEDLINE
    • Publication Information:
      Original Publication: Praha : Ceská lékarská spolecnost J. E. Purkyne,
    • Subject Terms:
      Acetylcholinesterase/*metabolism ; Cholinesterase Inhibitors/*pharmacology ; Enzyme Activators/*pharmacology ; Pralidoxime Compounds/*pharmacology ; Sarin/*pharmacology; Animals ; Brain/enzymology ; Enzyme Activation/drug effects ; In Vitro Techniques ; Rats
    • Abstract:
      The ability of the oxime HS-6 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] to reactive in vitro the enzyme acetylcholinesterase inhibited by the nerve agent sarin [O-isopropylmethylfluorophosphonate] was evaluated. The reactivators 2-PAM [2-hydroxyiminomethyl-1-methylpyridinium chloride], toxogonin [1,3-bis(4-hydroxyiminomethylpyridinium)-2-oxa-propane dichloride] and H-oxime HI-6 [1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] were chosen for comparison. The oxime HS-6 was an effective reactivator of sarin-inhibited AChE. It is not as effective as the H-oxime HI-6, but it is better than 2-PAM and obidoxime.
    • Accession Number:
      0 (Cholinesterase Inhibitors)
      0 (Enzyme Activators)
      0 (Pralidoxime Compounds)
      22625-23-6 (HS 6)
      B4XG72QGFM (Sarin)
      EC 3.1.1.7 (Acetylcholinesterase)
    • Publication Date:
      Date Created: 20040421 Date Completed: 20040601 Latest Revision: 20141120
    • Publication Date:
      20221213
    • Accession Number:
      15095579