Abstract: Introduction: This study aimed to investigate the effect of play-based occupational therapy on symptoms and participation in daily life activities in hospitalized children with cancer undergoing chemotherapy. Method: A total of 25 children (mean age = 9.28 ± 0.95 years, range = 7–12 years) with cancer undergoing chemotherapy were enrolled and randomly assigned to a play-based occupational therapy group (n = 12) or control group (n = 13). The intervention group received eight 1-hour play-based occupational therapy sessions, and the control group received traditional occupational therapy services. Participation in daily life activities, therapy-related symptoms, pain, anxiety, and fatigue were evaluated. Results: Total mean scores of participation in daily life activities in the intervention group in the diversity of activities (p = 0.001, d = 1.39), intensity of participation (p = 0.001, d = 1.86), with whom done (p = 0.005, d = 1.22), enjoyment (p = 0.003, d = 1.33), and parents' satisfaction (p = 0.003, d = 1.33) were significantly higher than the control group. Symptoms decreased in both groups; however, this trend had a significant difference in the intervention group for the therapy-related symptom checklist (p = 0.001, d = 1.68), pain (p = 0.001, d = 1.61), anxiety (p = 0.001, d = 1.58), and fatigue (p = 0.002, d = 1.39) scores. Conclusion: A 2-week course of inpatient play-based occupational therapy is an effective approach in the reduction of cancer symptoms, therapy-related symptoms, and the participation facilitation, of children with cancer in daily life activities. [ABSTRACT FROM AUTHOR]
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