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Wando Mount Pleasant Library
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
Brazilian green propolis promotes TNFR2 expression on regulatory T cells.
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![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Mikami, Norihisa1 (AUTHOR); Tani, Hiroko2 (AUTHOR); Kawakami, Ryoji1 (AUTHOR); Sugimoto, Atsushi1 (AUTHOR); Sakaguchi, Shimon1 (AUTHOR); Ikuta, Tomoki2 (AUTHOR)
- Source:
Food Science & Nutrition. Jun2021, Vol. 9 Issue 6, p3200-3208. 9p.- Subject Terms:
- Source:
- Additional Information
- Abstract: FoxP3+ regulatory T cells (Tregs) are needed to suppress inflammatory diseases and maintain immune homeostasis. The suppressive function of Tregs can be used to control autoimmune or inflammatory diseases; therefore, it is well studied how Tregs can be artificially up‐ or downregulated in vitro and in vivo, by using antibodies, chemical compounds, foods, and natural resources. Propolis is a famous functional food that has an anti‐inflammatory effect. However, the influences of propolis on Treg function have not been fully evaluated so far. Here, we demonstrated that Brazilian green propolis increases TNFR2 expression in Tregs via the IRF4/cMyc axis, and artepillin C was a major effective component of propolis on Tregs. These results indicate that propolis and artepillin C have the potential as Treg activators via TNFR2 expression and may be useful for the prevention and/or therapy of autoimmune or inflammatory diseases. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Food Science & Nutrition is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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