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Hepatocellular adenomas in the Turkish population: reclassification according to updated World Health Organization criteria.
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- Author(s): Deniz, Kemal; Umetsu, Sarah E; Ferrell, Linda; Yılmaz, Funda; Güllüoğlu, Mine; Sağol, Özgül; Doğusoy, Gülen B; Kırımlıoğlu, Hale; Turhan, Nesrin; Doran, Figen; Kepil, Nuray; Çelikel, Çiğdem A; Nart, Deniz; Özgüven, Banu Y; Ceyran, Bahar; Karadağ, Neşe; Kır, Gözde; Erden, Esra; Yılmaz, Güldal; Akyol, Gülen
- Source:
Histopathology; Jul2021, Vol. 79 Issue 1, p23-33, 11p- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Subject Terms:
- Abstract: Aims: Hepatocellular adenoma (HCA) is an uncommon liver neoplasm, and studies of HCA subtypes have been primarily limited to France, the USA, and Japan. The aim of this study was to describe the clinicopathological features of HCA subtypes in Turkey. Methods and results: The resection specimens of 59 cases diagnosed as 'hepatocellular adenoma' collected from 15 institutions were reviewed to confirm the diagnosis and to classify them according to the current World Health Organization 2019 classification. Immunostaining for glutamine synthetase, liver fatty acid‐binding protein, C‐reactive protein, β‐catenin and reticulin was performed. Of the 59 cases, 48 (81%) were diagnosed as HCA. We identified 24 (50%) hepatocyte nuclear factor 1α (HNF1α)‐inactivated HCAs, five (10%) inflammatory HCAs, 15 (32%) β‐catenin‐activated HCAs, three (6%) β‐catenin‐activated inflammatory HCAs, and one (2%) unclassified HCA. HCA patients were predominantly female (female/male ratio of 5:1); they had a median age of 34 years and a median tumour diameter of 60 mm. In the β‐catenin‐activated HCA group, nine cases (19%) showed cytoarchitectural atypia, and were also referred to as atypical hepatocellular neoplasms. In the β‐catenin‐activated HCA group, three cases (6%) showed focal areas supportive of transition to HCA. The original diagnosis of HCA was changed to well‐differentiated hepatocellular carcinoma in nine cases and to focal nodular hyperplasia in two cases. Conclusion: In our series, the major HCA subtype was HNF1α‐inactivated HCA. We found a low incidence of inflammatory‐type HCA. Our data also showed that β‐catenin‐activated hepatocellular neoplasms, including cases with atypical histology, constituted a relatively high proportion of the cases. These findings are in contrast to those of most other studies of HCA subtypes. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Histopathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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