[Clinical effectiveness and potential hazards of combined kordaron and quinidine therapy of patients with atrial fibrillation].

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  • Additional Information
    • Transliterated Title:
      Klinicheskaia éffektivnost' i potentsial'nyĭ risk kombinirovannoĭ terapii kordaronom i khinidinom bol'nykh mertsiatel'noĭ aritmieĭ.
    • Source:
      Publisher: Med. informat︠s︡ionnoe agentstvo Country of Publication: Russia (Federation) NLM ID: 2985204R Publication Model: Print Cited Medium: Print ISSN: 0023-2149 (Print) Linking ISSN: 00232149 NLM ISO Abbreviation: Klin Med (Mosk) Subsets: MEDLINE
    • Publication Information:
      Publication: Moskva : Med. informat︠s︡ionnoe agentstvo
      Original Publication: Moskva.
    • Subject Terms:
      Amiodarone/*administration & dosage ; Atrial Fibrillation/*drug therapy ; Heart/*drug effects ; Quinidine/*administration & dosage; Adult ; Aged ; Amiodarone/adverse effects ; Drug Therapy, Combination ; Electric Countershock ; Electrocardiography ; Female ; Humans ; Lidocaine/therapeutic use ; Male ; Middle Aged ; Quinidine/adverse effects ; Ventricular Fibrillation/chemically induced
    • Abstract:
      Clinical efficacy of and potential risk for complications from combined cordarone+quinidine treatment were studied in 52 patients with atrial fibrillation (AF). Out of 32 patients with a persistent pattern of the disease the sinus rhythm was recovered in 28 (87.5%) of the patients; out of 20 patients with paroxysmal pattern of AF resistant to routine anti-arrhythmic treatment, the sinus rhythm was recovered in 14 (70%) patients. Almost 50% Q-T prolongation was recorded in one patient with paroxysmal AF. Despite the withdrawal of the medication, 4 hours later ventricular tachycardia of the "pirouette" type arose that 2-3 minutes later was followed by ventricular fibrillation with clinical death. After effective electric defibrillation in the presence of lidocaine treatment ventricular fibrillation repeated 7 times. A total of 32 cardiac defibrillations were performed for 6 hours. The normalization of the Q-T interval was observed on the fourth day only. The patient was discharged from the hospital in a satisfactory condition.
    • Accession Number:
      98PI200987 (Lidocaine)
      ITX08688JL (Quinidine)
      N3RQ532IUT (Amiodarone)
    • Publication Date:
      Date Created: 19920301 Date Completed: 19920921 Latest Revision: 20131121
    • Publication Date:
      20231215
    • Accession Number:
      1507842