1‐Deoxyceramides – Key players in lipotoxicity and progression to type 2 diabetes?

Serum ether lipids, such as those containing a choline headgroup (O-PC), were previously found to be reduced in multiple (pre-) disease conditions, including, eg, in obesity, T2D, type 1 diabetes (T1D), and Alzheimer's disease. Despite the fact that certain lipid classes, such as LPCs and ether lipids, have been consistently found to be associated with T2D, the understanding of their potential pathophysiological role(s) remains lacking, highlighting the need for further studies. Ceramides are bioactive sphingolipids, comprised of sphingosine and a fatty acyl chain. [Extracted from the article]

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