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Complete genome sequence of the apicomplexan, Cryptosporidium parvum.
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- Additional Information
- Source:
Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
- Publication Information:
Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
- Subject Terms:
- Abstract:
The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma, the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development.
- Grant Information:
U01 AI 46397 United States AI NIAID NIH HHS
- Accession Number:
0 (Antiprotozoal Agents)
0 (DNA, Protozoan)
0 (Enzymes)
0 (Protozoan Proteins)
0 (Purines)
3K9958V90M (Ethanol)
- Publication Date:
Date Created: 20040327 Date Completed: 20040428 Latest Revision: 20220408
- Publication Date:
20231215
- Accession Number:
10.1126/science.1094786
- Accession Number:
15044751
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