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Biosynthetic origin of the rare nitroaryl moiety of the polyketide antibiotic aureothin: involvement of an unprecedented N-oxygenase.
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- Author(s): He J;He J; Hertweck C
- Source:
Journal of the American Chemical Society [J Am Chem Soc] 2004 Mar 31; Vol. 126 (12), pp. 3694-5.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print Cited Medium: Print ISSN: 0002-7863 (Print) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
- Publication Information:
Publication: Washington, DC : American Chemical Society
Original Publication: Easton, Pa. [etc.]
- Subject Terms:
- Abstract:
The antibiotic aureothin is a rare natural nitroaromatic compound produced by Streptomyces thioluteus. By labeling experiments, we demonstrate for the first time that p-nitrobenzoate (PNBA) serves as a polyketide synthase starter unit. Cloning, heterologous expression, and inactivation experiments reveal that this unusual primer is synthesized from p-aminobenzoate (PABA) by means of AurF, a novel N-oxygenase.
- Accession Number:
0 (Anti-Bacterial Agents)
0 (Chromones)
0 (Nitrobenzoates)
EC 1.13.- (Oxygenases)
G359FGQ2RB (aureothin)
G83NWR61OW (4-nitrobenzoic acid)
- Publication Date:
Date Created: 20040325 Date Completed: 20040707 Latest Revision: 20151119
- Publication Date:
20231215
- Accession Number:
10.1021/ja039328t
- Accession Number:
15038705
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