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West Ashley Library
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Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. - 8 p.m.
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
9 a.m. - 8 p.m.
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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John L. Dart Library
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Phone: (843) 722-7550
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9 a.m. - 8 p.m.
Phone: (843) 805-6930
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Proton pump inhibitors use and the risk of fatty liver disease: A nationwide cohort study.
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- Author(s): Pyo, Jeung Hui; Kim, Tae Jun; Lee, Hyuk; Choi, Sung Chul; Cho, Soo‐Jin; Choi, Yoon‐Ho; Min, Yang Won; Min, Byung‐Hoon; Lee, Jun Haeng; Kang, Minwoong; Lee, Yeong Chan; Kim, Jae J
- Source:
Journal of Gastroenterology & Hepatology; May2021, Vol. 36 Issue 5, p1235-1243, 9p- Subject Terms:
- Source:
- Additional Information
- Abstract: Background and Aim: Proton pump inhibitor (PPI)‐induced hypochondria can change the composition of the gut microbiota, inducing overgrowth of small bowel bacteria, which has been suggested to promote the development of fatty liver disease through the gut‐liver axis. In this study, we aimed to investigate the association between PPI use and the risk of fatty liver disease. Methods: A retrospective cohort study was conducted using the Korean National Health Insurance Service‐National Sample Cohort, a nationwide population‐based representative sample, from January 1, 2002, to December 31, 2015. PPI use was identified from treatment claims and considered as a time‐varying variable. Results: During 1 463 556 person‐years of follow‐up, 75 727 patients had at least one PPI prescription, and 3735 patients developed fatty liver disease. The hazard ratio for fatty liver disease comparing PPI users with non‐PPI users was 1.68 (95% confidence interval, 1.61–1.75). When adjusted for multiple confounders, including age, sex, body mass index, smoking, alcohol intake, exercise, income level, and comorbidities, the association was still significant (hazard ratio, 1.50; 95% confidence interval, 1.44–1.57). After considering the amounts of PPIs stratified by cumulative defined daily dose, the dose–response effect was observed until 180 days. Subgroup analysis also revealed that PPI use was correlated to an increased risk of fatty liver disease. Conclusions: This current national wide cohort study suggests that PPI use was associated with an increased risk of fatty liver disease compared with non‐use of PPIs. Clinicians should consider fatty liver as a potential risk when prescribing PPI. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Gastroenterology & Hepatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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